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Am J Transl Res:低强度脉冲超声可增强不同形貌钛表面骨髓间充质干细胞的成骨

2018-03-16 MedSci MedSci原创

低强度脉冲超声(LIPUS)是一种可促进骨生成的有前途的方法。然而,很少有研究报道这种技术对骨内种植体骨整合的影响,特别是对于不同的植体外形。本研究中,研究人员探究了LIPUS如何增强细胞与钛表面之间的初始相互作用及其潜在的调节机制。在LIPUS刺激或对照条件下,将大鼠的骨髓间充质干细胞(BMSCs)在两种类型的钛表面(光滑和SLA)上培养。结果显示,与对照组相比,LIPUS可明显促进种植体表面的

低强度脉冲超声(LIPUS)是一种可促进骨生成的有前途的方法。然而,很少有研究报道这种技术对骨内种植体骨整合的影响,特别是对于不同的植体外形。本研究中,研究人员探究了LIPUS如何增强细胞与钛表面之间的初始相互作用及其潜在的调节机制。

在LIPUS刺激或对照条件下,将大鼠的骨髓间充质干细胞(BMSCs)在两种类型的钛表面(光滑和SLA)上培养。结果显示,与对照组相比,LIPUS可明显促进种植体表面的细胞增殖,刺激微丝数量增加,伪足形成和细胞外基质矿化结节增多。通过LIPUS刺激两种钛表面上BMSCs的成骨相关基因(包括OPN,OCN,BMP-2,ALP,Runx2和Col-1)的表达上调。

综上所述,该研究结果表明,LIPUS增强了钛表面BMSCs的成骨细胞分化。LIPUS或是改善骨整合的潜在辅助治疗。

原始出处:

An Y, Song Y, et al., Effect of low-intensity pulsed ultrasound on the biological behaviors of bone marrow mesenchymal stem cells on titanium with different surface topographies. Am J Transl Res. 2018 Jan 15;10(1):67-76. eCollection 2018.

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    2018-10-24 30397613
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    2019-02-02 bsmagic9140
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1679689, encodeId=6d0b16e9689a6, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Wed Oct 24 21:04:00 CST 2018, time=2018-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815306, encodeId=5d4918153064c, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Tue May 01 02:04:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067320, encodeId=3fe9206e3206b, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Apr 08 07:04:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656964, encodeId=03de16569642d, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sat Feb 02 04:04:00 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705455, encodeId=822f1e05455da, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723a30986413, createdName=ying_wu, createdTime=Thu Feb 14 02:04:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351690, encodeId=0761135169060, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Mar 18 10:04:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-18 zhaojie88
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