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Hypertension:长期暴露于环境颗粒物与成人高血压发病率的动态变化

2019-07-15 xing.T MedSci原创

该研究结果表明,减少空气污染是降低心血管疾病风险的有效策略。

在过去几十年中,许多国家致力于减少空气污染。然而,人们对空气质量改善如何影响健康知之甚少。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员进行了一项研究以调查大型纵向队列中长期暴露于环境颗粒物(PM2.5)与高血压发病率动态变化之间的关系。

研究人员在2001年至2014年期间招募了134978名18岁或以上的成年人。所有参与者都接受了一系列标准体检,包括血压测量。研究人员使用基于卫星的高分辨率(1×1km 2)时空模型估算PM2.5浓度。长期暴露于PM2.5(ΔPM2.5)的变化定义为随访期间和前一次随访间测量值之间的差异,负值表示PM2.5空气质量改善。时间变化的Cox模型用于评估ΔPM2.5与高血压发生发展之间的关联。

结果表明,2002年、2003年和2004年PM2.5浓度增加,但2005年PM2.5开始下降。PM2.5每改变5μg/m3(即ΔPM2.5为5μg/m3)与高血压发病率变化16%相关(风险比为0.84; 95%CI为0.82-0.86)。分层和敏感性分析得到了类似的结果。研究人员发现PM2.5暴露的改善与高血压发病率降低有关。

该研究结果表明,减少空气污染是降低心血管疾病风险的有效策略。 

原始出处:

Daan L.K. de Jong.et al.Effects of Nilvadipine on Cerebral Blood Flow in Patients With Alzheimer Disease A Randomized Trial.Hypertension.2019.https://doi.org/10.1161/HYPERTENSIONAHA.119.12892

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    2019-10-16 lifestar
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    2019-12-15 feather89
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    2019-10-04 lisa449
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    2019-07-16 phoebeyan520

    学习了

    0

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