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BMJ:医生推荐超重人群进行低能量总膳食替代治疗的疗效分析

2018-10-01 xing.T MedSci原创

由此可见,与常规减肥支持相比,每周行为支持和提供810千卡/天的总膳食替代计划似乎是可以耐受,并且体重减轻更明显,心脏代谢疾病风险改善程度更大。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在评估低能量总膳食替代(TDR)计划在初级保健机构中常规治疗肥胖的有效性和安全性。

该研究为实用、双组、平行组、开放分组的随机对照试验。以英国牛津郡10个初级保健机构为基础。参与者为278名肥胖并寻求减肥支持的成年人:138人被分配到TDR计划组,140人被分配到常规治疗组。73%的参与者在12个月时重新进行测量。TDR计划包括每周行为学支持,治疗12周,以及每月支持,治疗3个月,配方食品在前8周内提供810千卡/天(3389千焦/天)作为唯一食物,然后再重新加入食物。常规治疗包括对练习减肥的行为支持以及适度能量限制的饮食计划。该研究的主要结局指标为12个月时体重变化。次要结局包括血管和代谢风险的生物学标志物,研究人员并记录了不良事件。

研究人员发现TDR组的参与者体重(-10.7 kg)比常规治疗组(-3.1 kg)减轻更多:调整后的平均差异为-7.2 kg(95%置信区间为-9.4至-4.9 kg)。TDR组45%的参与者和常规治疗组的15%参与者体重减轻10%或更多。与常规治疗组相比,TDR组在血管和代谢风险的生物学标志物方面表现出更大的改善。TDR组中11%的参与者和常规治疗组中12%的参与者经历了中度或更严重的不良事件。

由此可见,与常规减肥支持相比,每周行为支持和提供810千卡/天的总膳食替代计划似乎是可以耐受,并且体重减轻更明显,心脏代谢疾病风险改善程度更大。

原始出处:

Nerys M Astbury, et al. Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial.BMJ.2018; https://www.bmj.com/content/362/bmj.k3760

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    2018-11-20 gaoxiaoe
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    2018-10-03 zhaojie88
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    2018-10-01 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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