Baidu
map

J INTERN MED:COVID-19患者动脉僵硬度及其与临床结局的潜在关联

2021-03-06 MedSci原创 MedSci原创

COVID-19似乎与PWV升高有关,表明这类患者动脉僵硬度有所增加。较高的PWV可能与住院时间延长和死亡率增加有关。

2019新冠肺炎COVID-19)会扰乱血管内皮功能,但是COVID-19是否还会影响动脉僵硬度尚未明确。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,这项病例对照研究比较了伴有和伴有COVID-19的急性病患者的肱-踝动脉脉搏波传导速度(baPWV))和颈-股动脉脉搏波传导速度(cfPWV)。

研究人员将22名COVID-19患者(50%为女性患者,平均年龄为77 [67-84]岁)与22名年龄和性别匹配的对照者进行了比较。

在COVID-19患者中,baPWV(19.9 [18.4-21.0] vs. 16.0 [14.2-20.4],p=0.02)和cfPWV(14.3 [13.4-16.0] vs. 11.0 [9.5-14.6],p=0.01)高于对照者。在多元回归分析中,COVID-19独立地与较高的cfPWV(β=3.164,p=0.004)和baPWV(β=3.532,p=0.003)相关。COVID-19非幸存者的PWV值较高。在COVID-19幸存者中,PWV与住院时间长短有关。

由此可见,COVID-19似乎与PWV升高有关,表明这类患者动脉僵硬度有所增加。较高的PWV可能与住院时间延长和死亡率增加有关

原始出处:

Bertil Lindahl.et al.Poor long‐term prognosis in patients admitted with strong suspicion of acute myocardial infarction but discharged with another diagnosis.J INTERN MED.2021.https://onlinelibrary.wiley.com/doi/10.1111/joim.13272

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1843248, encodeId=9d77184324801, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Thu May 13 06:30:35 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297516, encodeId=6189129e5161b, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546765, encodeId=fed61546e656e, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546821, encodeId=f41e1546821dc, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610943, encodeId=26591610943d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1843248, encodeId=9d77184324801, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Thu May 13 06:30:35 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297516, encodeId=6189129e5161b, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546765, encodeId=fed61546e656e, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546821, encodeId=f41e1546821dc, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610943, encodeId=26591610943d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1843248, encodeId=9d77184324801, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Thu May 13 06:30:35 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297516, encodeId=6189129e5161b, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546765, encodeId=fed61546e656e, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546821, encodeId=f41e1546821dc, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610943, encodeId=26591610943d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1843248, encodeId=9d77184324801, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Thu May 13 06:30:35 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297516, encodeId=6189129e5161b, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546765, encodeId=fed61546e656e, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546821, encodeId=f41e1546821dc, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610943, encodeId=26591610943d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1843248, encodeId=9d77184324801, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Thu May 13 06:30:35 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297516, encodeId=6189129e5161b, content=<a href='/topic/show?id=c0385134ab' target=_blank style='color:#2F92EE;'>#COVID-19患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5134, encryptionId=c0385134ab, topicName=COVID-19患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546765, encodeId=fed61546e656e, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546821, encodeId=f41e1546821dc, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610943, encodeId=26591610943d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 08 03:30:35 CST 2021, time=2021-03-08, status=1, ipAttribution=)]

相关资讯

JAHA:体育活动量和方式与动脉僵硬度之间的关联

高强度体育活动与较低的颈动脉至股动脉脉搏波速度有关,但定期活动者与周末或兼职时参加剧烈运动者之间没有差异。

Hypertension:盐皮质激素受体拮抗剂对动脉僵硬度和内皮功能的影响

当前的荟萃分析表明MRA对PWV、增强指数和血流介导的扩张具有益处。

JAHA:收缩压和动脉僵硬度进展之间的关系

基线收缩压与动脉僵硬度进展有关,与年龄无关。

Diabetes Obes Metab:尿酸、肾血流动力学与动脉僵硬度的关系随1型糖尿病史的变化

由此可见,仅在病程较长的T1D老年人中观察到较低GFR、较高动脉硬度和RAAS活化与较高PUA之间的关系。T1D持续时间可以改变PUA、肾血流动力学功能和RAAS激活之间的关联,导致肾血管收缩和缺血。进一步的工作必须确定通过药物降低PUA是否可以预防或逆转长期T1D的有害血液动力学和神经激素后遗症,从而改善患者临床结局。

ATVB:总白细胞计数介导动脉僵硬度与2型糖尿病风险之间的关系

由此可见,动脉僵硬度的增加可能会增加中老年人T2DM的患病风险,这在一定程度上是由白细胞总数所介导。

Hypertension:动脉僵硬度对COVID-19住院患者全因死亡率的影响

该研究的数据表明AS和入院SBP<120 mmHg对COVID-19住院患者的全因死亡率具有预测价值。

Baidu
map
Baidu
map
Baidu
map