英国NICE对罗氏的PD-L1单抗Tecentriq治疗晚期乳腺癌say

2019-10-05 不详 MedSci原创

英国国家卫生与保健研究院表示，希望罗氏公司确保其PD-L1抑制剂Tecentriq（atezolizumab）针对需求严重未得到满足的晚期乳腺癌具有成本效益。成本监管机构发布了准则草案，该准则草案否决将Tecentriq用于已经扩散到身体其他部位的乳腺癌的治疗，并裁定该药物对于NHS的使用而言过于昂贵。

英国国家卫生与保健研究院表示，希望罗氏公司确保其PD-L1抑制剂Tecentriq（atezolizumab）针对需求严重未得到满足的晚期乳腺癌具有成本效益。成本监管机构发布了准则草案，该准则草案否决将Tecentriq用于已经扩散到身体其他部位的乳腺癌的治疗，并裁定该药物对于NHS的使用而言过于昂贵。

Tecentriq是第一种专门针对PD-L1表达为1％或更高，联合化疗药物nab-paclitaxel治疗三阴性乳腺癌的免疫疗法。适用于未曾接受过转移性疾病化疗且无法手术切除肿瘤的患者。

有证据表明，与安慰剂加纳布-紫杉醇相比，该组合可将无进展生存期延长约2.5个月（分别为7.5个月和5.0个月），并使总生存期增加约9.5个月（分别为25.0个月和15.5个月）。但是，NICE指出，该公司没有提交任何直接比较Tecentriq加nab-紫杉醇与现阶段使用的其他治疗方法的试验数据，并且委员会认为对这些治疗方法进行间接比较的分析是"不可靠且缺乏有效性"。

它补充说，当使用nab-paclitaxel替代NHS中的当前治疗药物时，NICE的独立委员会不能推荐atezolizumab加nab-paclitaxel作为一种具有成本效益的NHS资源。以全价标价治疗7.5个月， atezolizumab疗程的费用为39981英镑，但该公司为NHS提供了保密折扣。

原始出处：

http://www.pharmatimes.com/news/nice_draft_no_for_roches_tecentriq_1311777

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2020-06-21 shock_melon

#TEC#

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2019-10-07 smartjoy

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2019-10-07 fusion

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2019-10-07 ms117281293605716

#PD-L1单抗Tecentriq#

79 0
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2019-10-07 lfyang

#Tecentriq#

73 0
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2019-10-07 lvygwyt2785

#英国NICE#

93 0
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2019-10-07 ylz8407

#PD-L1单抗#

76 0

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