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JHBPS:活体肝移植患者红细胞分布宽度与输血的关系:倾向评分分析

2022-04-27 网络 网络

本研究调查了 LDLT 受者的红细胞分布宽度 (RDW) 与术中输血之间的关系。研究证实术前 RDW 是 LDLT 受者术中输血的潜在预测指标

肝移植(LT)是终末期肝病患者最复杂的手术之一,是外科医生和麻醉师面临的巨大挑战。尽管人们努力寻找肝移植术中出血和输血的预测因子,但目前仅获得的信息有限。红细胞分布宽度(RDW)是测量血液样本中红细胞大小的变化和标准全血细胞计数的一部分,最近的几项研究报道,RDW与某些疾病和程序的出血风险和输血相关。

然而,关于预测活体肝移植(LDLT)输血的指标的信息是有限的。本研究调查了 LDLT 受者的红细胞分布宽度 (RDW) 与术中输血之间的关系。

本研究分析了 2010 年 1 月-2019 年 10 月期间接受 LDLT 的 2546 名患者。根据术前 RDW 截止水平(<14.4 和≥14.4)将患者分为两组。研究人员进行了多变量回归分析来评估RDW与术中输血之间的关联,还进行了倾向评分匹配分析,以比较两组术中输血的发生率。RDW 的预测能力通过接受者操作特征 (ROC)、综合辨别改进 (IDI) 和净重分类改进 (NRI) 分析进行评估。

图1:活体供肝移植患者术中输血时红细胞分布宽度的roc曲线

 

表1:术中输血调整RDW截断水平(≥14.4)

表2:评价RDW对预测术中输血的附加价值.*模型1=年龄+性别+BMI+DM+HTN+剖腹手术史+CAD+门静脉血栓形成+腹水+MELD评分+病因学+HCC+血红蛋白<12+INR>1.3+血小板<70k+纤维蛋白原<160。†模型2=模型1+RDW≥14.4

在多变量逻辑分析中,RDW  14.4 与术中输血显着相关(优势比 [OR]:1.53,95% 置信区间 [CI]:1.13-2.06,P = 0.005)。两组术中输血发生率在匹配前(54.1% vs. 91.6%,P <0.001)和匹配后(71.6% vs. 79.8%,P =0.004)差异有统计学意义。RDW 对术中输血具有预测能力(NRI中P <0.001,IDI 中P =0.035)。

总的来说,研究人员发现术前RDW≥14.4与LDLT患者术中输血密切相关。这些结果表明,术前RDW可以作为LDLT受者术中输血的有用预测指标。

 

原始出处:

Sim, J.-H., Kwon, H.-M., Jun, I.-G., Kim, S.-H., Kim, B., Kim, S., Song, J.-G. and Hwang, G.-S. (2022), Association between red blood cell distribution width and blood transfusion in patients undergoing living donor liver transplantation: propensity score analysis. J Hepatobiliary Pancreat Sci. Accepted Author Manuscript. https://doi.org/10.1002/jhbp.1163.

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    2023-03-11 tsing_hit
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    2022-04-28 windight
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