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GUT: COVID-19病毒对肝硬化患者生存率的影响

2020-07-18 MedSci原创 MedSci原创

COVID-19患者如果患有各种其他合并症那么其预后是不良的。数据显示,肝硬化患者可能是不良预后的高风险患者。但是,尚缺乏肝硬化+ COVID-19患者与仅COVID-19和仅肝硬化患者之间的结局比较

背景及目的:

COVID-19患者如果患有各种其他合并症那么其预后是不良的。数据显示,肝硬化患者可能是不良预后的高风险患者。但是,尚缺乏肝硬化+ COVID-19患者与仅COVID-19和仅肝硬化患者之间的结局比较。这项研究的目的是进行这些比较。

方法

研究人员进行了一项针对肝硬化+ COVID-19住院患者与年龄/性别匹配的仅COVID-19或单纯肝硬化患者的多中心研究。比较了COVID-19和肝硬化的特征,器官衰竭的发展以及慢性肝功能衰竭(ACLF)和死亡率。

结果

来自七家医院的37例肝硬化+ COVID-19患者与108例COVID-19患者和127例肝硬化患者被纳入研究。种族/民族相似。肝硬化+ COVID-19患者的死亡率高于COVID-19患者(30%vs 13%,p = 0.03),但在肝硬化+ COVID-19患者和肝硬化患者之间死亡率却不高(30%vs 20%,p = 0.16)。肝硬化+ COVID-19的患者与仅COVID-19的患者具有相同的呼吸道症状,胸部表现以及重症监护病房转移和通气率。但是,肝硬化+ COVID-19患者的查尔森合并症指数更差(CCI 6.5±3.1VS 3.3±2.5,p <0.001),GI症状降低,乳酸含量更高。单纯肝硬化患者的肝硬化相关并发症较高,与肝硬化+ COVID-19的患者相比,终末期肝病(MELD)评分的最高模型和更低的BiPAP需求。

结论

本项研究表明年龄/性别匹配的肝硬化+ COVID-19患者与单独的肝硬化患者相比具有相似的死亡率,但高于单独的COVID-19患者。

原始出处:

Jasmohan S Bajaj. Et al. Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort. GUT. 2020.

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1932679, encodeId=758819326e95f, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Wed Jul 29 11:50:02 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256774, encodeId=1c9e1256e74de, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Mon Jul 20 00:50:02 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803309, encodeId=d7e580330963, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJp0sD8Z3gbQpmzBtwg9CW7YicibuHSzMIfhBANYvGZiaEcH2gk0IrjXgRzR231rEUtXkHIBBbvbe6Zw/132, createdBy=80725261937, createdName=wangzheng00, createdTime=Sun Jul 19 14:53:45 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046447, encodeId=7125104644e1f, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jul 18 12:50:02 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-19 wangzheng00

    学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1932679, encodeId=758819326e95f, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Wed Jul 29 11:50:02 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256774, encodeId=1c9e1256e74de, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Mon Jul 20 00:50:02 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803309, encodeId=d7e580330963, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJp0sD8Z3gbQpmzBtwg9CW7YicibuHSzMIfhBANYvGZiaEcH2gk0IrjXgRzR231rEUtXkHIBBbvbe6Zw/132, createdBy=80725261937, createdName=wangzheng00, createdTime=Sun Jul 19 14:53:45 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046447, encodeId=7125104644e1f, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Jul 18 12:50:02 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-18 guging

    谢谢!最新的信息读起来就是收获大

    0

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