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Sci Adv:新生成的血管竟是癌细胞“越吃越肥”的罪魁祸首!

2017-10-27 佚名 medicalxpress

恶性肿瘤的生长需要营养,所以他们分泌一些因素促进新血管的形成来养活自己。研究人员早就知道,在低氧环境中肿瘤的中心会发送这些因素,近期,伊利诺斯州大学的研究人员的一项新研究发现,黑色素瘤边缘的茎状细胞非常可疑。新研究发表在《科学》杂志上。

恶性肿瘤的生长需要营养,所以他们分泌一些因素促进新血管的形成来养活自己。研究人员早就知道,在低氧环境中肿瘤的中心会发送这些因素,近期,伊利诺斯州大学的研究人员的一项新研究发现,黑色素瘤边缘的茎状细胞非常可疑。新研究发表在《科学》杂志上。

研究人员在报告中指出,“癌症的灵活性是一个大危险,癌症可以建立自己的生存网,协调自己的生存和传播能力。在实验室条件下,我们看到各种信号广泛的发出,我们还需要进一步的研究来确定不同类型癌症后援物的不同。”

此次研究以黑色素瘤为主要研究对象,研究人员发现瘤是高度弯曲的,被细胞紧紧压实。癌细胞边缘有一些像干细胞似的茎状细胞,它们具备传播癌细胞的功能,在此次研究中,研究人员重点观察了这些茎状细胞,发现了他们产生信号的化学物质组合。

研究小组在实验室中模拟了身体组织内环境,他们还比较了外围细胞弯曲的形状,以及平滑肿瘤细胞的不同,结果发现,暴露于紧张拓扑周边的细胞可以分泌更高水平的生长因子,促进血管生成和生长,为癌细胞提供生长和扩散所需要的养分。”

“这是一个有趣的发现,接下来,我们就要找到破坏心血管生成的方法,而且,我们还需要进一步的研究来确定这一机制是否也适用于其他癌症。”

原始出处:

Junmin Lee, Amr A. Abdeen, Jamila Hedhli, et.al. Melanoma topology reveals a stem-like phenotype that promotes angiogenesis. Science Advances  25 Oct 2017

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    2018-03-10 Drhzm308

    谢谢.学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=294652, encodeId=d842294652e0, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sat Mar 10 00:34:56 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256950, encodeId=0919256950c1, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Oct 29 12:50:19 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252392, encodeId=8be0125239207, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Oct 29 08:35:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256486, encodeId=11fc25648604, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4cyIbibqa2VuNGCKeyRxITYNqLTIaoFo3Jx2LSawp8yrFSs1CIXKv1jyXV97ecnxhhktGKkPP9onfJFZCbiayLgic/0, createdBy=3f1c1956638, createdName=1e127dd4m40(暂无匿称), createdTime=Fri Oct 27 23:16:11 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-10-29 大爰

    学习了谢谢分享!!

    0

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    2017-10-29 yxch36
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    2017-10-27 1e127dd4m40(暂无匿称)

    学习了

    0

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