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BMJ:113名新冠肺炎死亡病例临床特征研究

2020-03-28 网络 网络

研究发现,新冠肺炎病毒可引起肺部和全身炎症,导致高危患者出现多器官衰竭,死亡患者的常见的严重并发症包括,急性呼吸窘迫综合征、呼吸衰竭、脓毒症、急性心脏损伤和心力衰竭

近日研究人员描述了冠状病毒病2019(Covid-19)死亡患者的临床特征
 
研究在中国武汉同济医院开展,截至2020年2月28日,其中死亡患者113例,治愈出院161例,从电子病历中提取相关资料。
 
研究发现,死亡患者的年龄显著高于治愈出院患者(68 vs 51岁),男性患者的死亡风险较高,男性死亡患者83例,占73%,男性治愈患者88例,占55%。死亡患者中,最常见的共病为高血压和其他心血管疾病,其中死亡患者中高血压患者54例(48%),其他心血管疾病16例(14%);而治愈患者中高血压39例(24%),其他心血管疾病7例(4%)。死亡患者最常见的症状包括呼吸困难(70例,62%)、胸闷(55例,49%)和意识障碍(25例,22%),而治愈患者中上述症状分别只有50例(31%)、48例(30%)以及1例(1%)。平均症状出现到患者死亡时间为16天。56例死亡患者(50%)出现白细胞增多,而治愈患者中仅6例(4%),而死亡和治愈患者中,淋巴细胞减少症状分别为103例(91%)和76例(47%)。死亡病例中,丙氨酸氨基转移酶、天冬氨酸转氨酶、肌酐、肌酸激酶、乳酸脱氢酶、肌钙蛋白I、N端前脑钠肽和d-二聚体的浓度显著高于治愈患者。死亡患者的常见并发症包括急性呼吸窘迫综合征(113例,100%)、I型呼吸衰竭(18例,51%)、脓毒症(113例,100%)、急性心脏损伤(72例,77%)、心力衰竭(41例,49%)、碱中毒(14例,40%)、高钾血症(42例,37%)、急性肾损伤(28例,25%)和缺氧性脑病(23例,20%)。伴有心血管共病患者出现心血管并发症风险较高,但无论心血管疾病史,急性心脏损伤和心力衰竭在死亡患者中更为常见。
 
研究发现,新冠肺炎病毒可引起肺部和全身炎症,导致高危患者出现多器官衰竭,死亡患者的常见的严重并发症包括,急性呼吸窘迫综合征、呼吸衰竭、脓毒症、急性心脏损伤和心力衰竭。
 
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    2021-03-13 gaoxiaoe
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    2020-03-28 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2020-03-28 1226a71am04(暂无昵称)

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1848988, encodeId=da2718489884a, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Mar 13 15:13:20 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842924, encodeId=b1181842924b8, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Mon Sep 07 20:13:20 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772127, encodeId=15821e721275d, content=<a href='/topic/show?id=122b63381b3' target=_blank style='color:#2F92EE;'>#死亡病例#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63381, encryptionId=122b63381b3, topicName=死亡病例)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59d938370790, createdName=xuqianhua, createdTime=Mon Jun 29 02:13:20 CST 2020, time=2020-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027574, encodeId=e35a102e57401, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Mar 28 13:13:20 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381071, encodeId=aa9e3810e1f9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ea82329997, createdName=1226a71am04(暂无昵称), createdTime=Sat Mar 28 12:17:42 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381068, encodeId=ded238106803, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/y6Sk2KiaDibWSs0icexcRzKWXKao9dILdyaB6olvWApA1uiaapa4T9XMiaU7hTZA04uj2iavabfdCT5iaO6AYue5qSJ7MzXaAVSqh6j/0, createdBy=08e01983553, createdName=执迷不悔, createdTime=Sat Mar 28 10:24:21 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-03-28 执迷不悔

    学习了

    0

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