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Blood:MYC和BCL2拷贝数变异对DLBCL肿瘤形态的影响及MYC-IHC假阴性的机制

2020-11-12 MedSci原创 MedSci原创

当世界卫生组织(WHO)将具有MYC、BCL2和/或BCL6重排的高度恶性B细胞淋巴瘤(HGBL-DH/TH)定义为临床类别时,重排是唯一纳入的结构变异(SV)。拷贝数变异(CNV)是另一种SV,常与

当世界卫生组织(WHO)将具有MYC、BCL2和/或BCL6重排的高度恶性B细胞淋巴瘤(HGBL-DH/TH)定义为临床类别时,重排是唯一纳入的结构变异(SV)。拷贝数变异(CNV)是另一种SV,常与基因异常表达有关。已经提出的一种“非典型双重打击”实体,涵盖除了共发生易位以外同时存在MYC和BCL2结构变异的肿瘤。虽然携带MYC和BCL2重排的肿瘤之间共有的基因表达特征(DHITsig)证实了这两种肿瘤具有共同的生物学基础,但MYC和BCL2 CNV的生物学意义还需要进一步阐明。

研究人员通过荧光原位杂交(FISH)对802例具有弥漫性大B细胞淋巴瘤(DLBCL)形态的新发肿瘤进行了MYC和BCL2 CNV的综合分析。

BCL2 CNV与表达增加相关,而MYC CNV则与表达增加无关。此外,在非典型双重打击的背景下,MYC和BCL2 CNV没有提供与HGBL-DH/TH-BCL2相似的基因表达谱。最后,虽然MYC IHC已被建议作为FISH检测的筛查工具,但研究人员观察到了MYC重排与IHC阳性解偶联的两种机制:1)MYC mRNA低表达;2)MYC基因第11位氨基酸残基(MYC-N11S)由单核苷酸多态性引起天冬酰胺-丝氨酸替代的免疫组织化学(IHC)染色呈假阴性。

综上所述,本研究结果支持目前从HGBL-DH/TH中排除MYC和BCL2 CNV的说法,并强调了基于分子的分类系统能够识别FISH和IHC未能完全捕获的具有共同生物学特征的肿瘤。

原始出处:

Collinge Brett J,Ben-Neriah Susana,Chong Lauren C et al. Impact of MYC and BCL2 structural variants in tumors of DLBCL morphology and mechanisms of false-negative MYC IHC. Blood, 2020. DOI:10.1182/blood.2020007193

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898796, encodeId=90d1898e9698, content=评论怎么不成功呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1875434295, createdName=ms4000001860330064, createdTime=Thu Nov 12 20:32:42 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039347, encodeId=6bd7103934eb0, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Nov 12 19:51:26 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898785, encodeId=f72c898e8523, content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
    2020-11-14 guihongzh
  5. 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content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898796, encodeId=90d1898e9698, content=评论怎么不成功呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1875434295, createdName=ms4000001860330064, createdTime=Thu Nov 12 20:32:42 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039347, encodeId=6bd7103934eb0, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Nov 12 19:51:26 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898785, encodeId=f72c898e8523, content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
    2020-11-14 cathymary
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898796, encodeId=90d1898e9698, content=评论怎么不成功呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1875434295, createdName=ms4000001860330064, createdTime=Thu Nov 12 20:32:42 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039347, encodeId=6bd7103934eb0, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Nov 12 19:51:26 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898785, encodeId=f72c898e8523, content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
    2020-11-14 Boyinsh
  8. [GetPortalCommentsPageByObjectIdResponse(id=1983926, encodeId=e0e3198392605, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Tue Jul 13 14:51:26 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019229, encodeId=f156201922900, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, 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content=<a href='/topic/show?id=e58d60299c' target=_blank style='color:#2F92EE;'>#DLBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6029, encryptionId=e58d60299c, topicName=DLBCL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Sat Nov 14 07:51:26 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446597, encodeId=c9db144659e8a, content=<a href='/topic/show?id=1f8a326e6f' target=_blank style='color:#2F92EE;'>#BCL2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3267, encryptionId=1f8a326e6f, topicName=BCL2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fdbf5248081, createdName=Boyinsh, createdTime=Sat Nov 14 07:51:26 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898796, encodeId=90d1898e9698, content=评论怎么不成功呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1875434295, createdName=ms4000001860330064, createdTime=Thu Nov 12 20:32:42 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039347, encodeId=6bd7103934eb0, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Nov 12 19:51:26 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898785, encodeId=f72c898e8523, content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
    2020-11-12 ms4000001860330064

    评论怎么不成功呢

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1983926, encodeId=e0e3198392605, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Tue Jul 13 14:51:26 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019229, encodeId=f156201922900, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, 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content=<a href='/topic/show?id=e58d60299c' target=_blank style='color:#2F92EE;'>#DLBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6029, encryptionId=e58d60299c, topicName=DLBCL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Sat Nov 14 07:51:26 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446597, encodeId=c9db144659e8a, content=<a href='/topic/show?id=1f8a326e6f' target=_blank style='color:#2F92EE;'>#BCL2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3267, encryptionId=1f8a326e6f, topicName=BCL2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fdbf5248081, createdName=Boyinsh, createdTime=Sat Nov 14 07:51:26 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898796, encodeId=90d1898e9698, content=评论怎么不成功呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1875434295, createdName=ms4000001860330064, createdTime=Thu Nov 12 20:32:42 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039347, encodeId=6bd7103934eb0, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Nov 12 19:51:26 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898785, encodeId=f72c898e8523, content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
    2020-11-12 肿肿

    机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898796, encodeId=90d1898e9698, content=评论怎么不成功呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1875434295, createdName=ms4000001860330064, createdTime=Thu Nov 12 20:32:42 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039347, encodeId=6bd7103934eb0, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Nov 12 19:51:26 CST 2020, time=2020-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898785, encodeId=f72c898e8523, content=喜欢梅斯医学,分享知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2a25330277, createdName=148ca0a9m16暂无昵称, createdTime=Thu Nov 12 19:45:37 CST 2020, time=2020-11-12, status=1, ipAttribution=)]
    2020-11-12 148ca0a9m16暂无昵称

    喜欢梅斯医学,分享知识

    0

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人类基因组中多达18,000个假基因,其中三分之二能够被转录。越来越多的证据表明,假基因具有功能作用,能够潜在地调节蛋白质编码基因的转录水平及转录后水平。

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