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ASCO2017:系统治疗作为各型乳腺癌脑转移的**

2017-06-05 zhangfan MedSci原创

所有乳腺癌脑转移患者都应当接受全身系统治疗

近日研究人员根据乳腺癌的生物学亚型、脑转移(BM)病灶数以及局部治疗后的全身治疗情况评估乳腺癌BM患者的存活率。

研究包含了2003-15年间735名乳腺癌脑转移患者,97%的患者接受全脑放疗,19%接受神经外科治疗,74%接受系统性全身治疗。714名乳腺癌患者的生物亚型包括:三阴性(TNBC), HER2+ER/PR-, HER2+/ER/PR+和 ER/PR+HER2-。

研究发现,对于不同生物亚型的脑转移患者(TNBC, HER2+ER/PR-, HER2+/ER/PR+ 以及鲁米诺病),中位生存期分别为 4, 8, 10 和9 个月(p < 0.001)。系统治疗的不同亚型脑转移患者(TNBC, HER2+ER/PR-, HER2+/ER/PR+ 以及鲁米诺病),中位生存期分别为6, 10, 14, 11个月,未经系统治疗的不同亚型脑转移患者(TNBC, HER2+ER/PR-, HER2+/ER/PR+ 以及鲁米诺病),中位生存期分别为2, 3, 2, 2 个月。单一病灶脑转移治疗患者中位生存期为15个月,不治疗为5个月;多病灶脑转移治疗患者中位生存期为28个月,不治疗为6个月。多病灶不同亚型脑转移治疗患者(TNBC, HER2+ER/PR-, HER2+/ER/PR+ 以及鲁米诺病),中位生存期分别为16, 28, 28, 28 个月,不治疗为 6, 7, 7 和7个月。

研究认为,三阴性乳腺癌脑转移患者预后最差,在常规治疗后的全身系统治疗可显著延长患者生存期。根据目前的认识,所有乳腺癌脑转移患者都应当接受全身系统治疗。

原始出处:


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    2018-03-16 quxin068
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    2017-06-07 luominglian113

    学习了,谢谢分享

    0

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    2017-06-06 1e1263e3m20(暂无匿称)

    长见识了,多谢分享

    0

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    2017-06-06 jacob9231

    学习了谢谢分享

    0

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    2017-06-06 189****7206

    学习了谢谢分享。

    0

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    2017-06-05 虈亣靌

    讲解的非常好,值得学习

    0

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    2017-06-05 wxl882001

    学习一下

    0

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