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J Periodontal Implant Sci:静磁场促进成骨细胞/成牙骨质细胞分化

2017-11-04 MedSci MedSci原创

虽然静态磁场(SMF)已用于牙修复体和种植体骨整合,其对牙周再生细胞中成骨细胞和成牙骨质细胞分化的生物学作用仍然未知。本研究旨在探讨SMFs(15 mT)对人成骨细胞、牙周膜细胞(PDLCs)和成牙骨质细胞分化的成骨细胞和成牙骨质细胞分化的影响,并探讨这些影响的可能机制。通过碱性磷酸酶(ALP)活性评估分化情况,使用茜素红染色和钙含量观察矿化结节形成,通过逆转录聚合酶链式反应(RT-PCR)评估的

虽然静态磁场(SMF)已用于牙修复体和种植体骨整合,其对牙周再生细胞中成骨细胞和成牙骨质细胞分化的生物学作用仍然未知。本研究旨在探讨SMFs(15 mT)对人成骨细胞、牙周膜细胞(PDLCs)和成牙骨质细胞分化的成骨细胞和成牙骨质细胞分化的影响,并探讨这些影响的可能机制。

通过碱性磷酸酶(ALP)活性评估分化情况,使用茜素红染色和钙含量观察矿化结节形成,通过逆转录聚合酶链式反应(RT-PCR)评估的标志物mRNA的表达。Western blotting和免疫细胞化学分析信号通路。

结果显示,早期标志ALP的活性和晚期标志物基质矿化和钙含量以及成骨细胞、PDLCs和成牙骨质细胞中的成骨细胞和成牙骨质特异性基因的表达增强。SMFs上调Wnt蛋白的表达,并增加糖原合成酶激酶-3β(GSK-3β)的磷酸化和总β-catenin蛋白的表达。此外,还激活了p38和c-Jun N端激酶(JNK)丝裂原活化蛋白激酶(MAPK)和核因子κB(NF-κB)通路。

总之该研究结果表明,SMF处理增强成骨细胞、成牙骨质细胞和PDLCs中成骨细胞和/或成牙骨质细胞的分化。这些发现提供了SMFs有益的成骨和/或牙骨质增生作用的分子基础,可能有助于在骨再生过程中和牙周病患者中刺激骨或牙骨质形成。

原始出处:

Eun-Cheol Kim, Jaesuh Park, Iet al., Static magnetic fields promote osteoblastic/cementoblastic differentiation in osteoblasts, cementoblasts, and periodontal ligament cells. J Periodontal Implant Sci. 2017 Oct; 47(5): 273–291. Published online 2017 Oct 30. doi: 10.5051/jpis.2017.47.5.273

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    2018-05-21 xuyu
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    2018-06-14 feather89
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    2018-04-25 xuyong536
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    2017-11-06 zhaojie88
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    2017-11-06 Eleven17
Baidu
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Baidu
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Baidu
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