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Vasc Med:血浆同型半胱氨酸和叶酸浓度与高风险个体颈动脉粥样硬化之间的关系

2019-08-28 sunshine 译 MedSci原创

已知同型半胱氨酸是动脉粥样硬化的危险因素。目前尚未在血管疾病的高危人群中彻底探究血浆总同型半胱氨酸(tHcy)浓度与颈动脉粥样硬化之间的关联。本研究通过测量923例血管疾病或糖尿病患者的颈动脉内膜中层厚度(IMT)和斑块钙化来评估颈动脉粥样硬化。探究了与tHcy和血浆叶酸浓度的关联。平均和单个最大颈动脉IMT分别为1.27 +/- 0.34 mm和2.41 +/- 0.83 mm。平均节段斑块钙化

已知同型半胱氨酸是动脉粥样硬化的危险因素。目前尚未在血管疾病的高危人群中彻底探究血浆总同型半胱氨酸(tHcy)浓度与颈动脉粥样硬化之间的关联。

本研究通过测量923例血管疾病或糖尿病患者的颈动脉内膜中层厚度(IMT)和斑块钙化来评估颈动脉粥样硬化。探究了与tHcy和血浆叶酸浓度的关联。

平均和单个最大颈动脉IMT分别为1.27 +/- 0.34 mm和2.41 +/- 0.83 mm。平均节段斑块钙化评分为27.8%。tHcy与平均值(r = 0.13; p <0.001)和单个最大(r = 0.12; p <0.001)颈动脉IMT相关。tHcy四分位数的平均和单个最大颈动脉IMT逐渐增加(趋势p <0.0001)。校正其他心血管危险因素后,这些关联的显著性消失。单变量和多变量分析结果显示,血浆叶酸和平均最大颈动脉IMT之间呈负相关的趋势。然而,在多次校正后,斑块钙化评分在tHcy的四分位数上增加(p <0.01)而在血浆叶酸浓度的四分位数上下降(p <0.05)。

总之,在高风险个体中,tHcy和低叶酸浓度仅与颈动脉IMT弱相关。相反,我们发现其与斑块钙化评分的独立关联,这是一种更先进的动脉粥样硬化的衡量标准。降低tHcy对颈动脉粥样硬化和中风预防的影响值得进一步研究。

原始出处:

Held C, Sumner G, et al., Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the Homocysteine and Atherosclerosis Reduction Trial (HART). Vasc Med. 2008 Nov;13(4):245-53. doi: 10.1177/1358863X08092102.

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1938997, encodeId=fb95193899eb7, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Apr 19 11:50:00 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944613, encodeId=b64c19446136a, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sun Nov 10 11:50:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843555, encodeId=c0f118435558d, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Tue Jan 28 10:50:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862104, encodeId=8cee1862104a7, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri Apr 03 00:50:00 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459374, encodeId=89dd14593e464, content=<a href='/topic/show?id=477610056158' target=_blank style='color:#2F92EE;'>#颈动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100561, encryptionId=477610056158, topicName=颈动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88db6138923, createdName=经常头晕, createdTime=Fri Aug 30 11:50:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544588, encodeId=83dd1544588c7, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Fri Aug 30 11:50:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609965, encodeId=4b8c160996541, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 30 11:50:00 CST 2019, time=2019-08-30, status=1, ipAttribution=)]
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