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AJG: 原发性硬化性胆管炎患者行粪便微生物移植的治疗效果分析

2019-07-14 不详 MedSci原创

原发性硬化性胆管炎(PSC)是一种胆汁淤积性肝病,目前没有有效的药物。先前有文献描述了与PSC相关的肠道微生物群的变化。因此,本项研究的目的是评估FMT后PSC患者的肝酶,微生物群和代谢组学特征变化。

背景及目的:
原发性硬化性胆管炎(PSC)是一种胆汁淤积性肝病,目前没有有效的药物。先前有文献描述了与PSC相关的肠道微生物群的变化。因此,本项研究的目的是评估FMT后PSC患者的肝酶,微生物群和代谢组学特征变化。

方法:
对PSC并发炎症性肠病和碱性磷酸酶(ALP)大于正常上限1.5倍的患者进行开放性试验研究。患者通过结肠镜检查进行单次FMT。在基线和FMT后第1,4,8,12和24周进行肝酶谱和粪便微生物组和代谢组学分析。主要结果是安全性分析,次要结果是FMT后第24周ALP水平从基线降低≥50%; 并评估了粪便微生物群(通过16S rRNA基因谱分析)和代谢组学动态。

结果:
本项研究共有10名患者接受了FMT。9名患者患有溃疡性结肠炎,1名患有克罗恩氏结肠炎。平均基线ALP水平为489U / L。总体而言,30%(3/10)的ALP水平降低了≥50%。FMT后所有患者的多样性最早出现在第1周(P <0.01)。重要的是,FMT后患者的丰富的操作分类单位与ALP水平降低相关(P = 0.02)。

讨论:
本项研究证明PSC患者进行FMT是安全的。此外,微生物的植入可能改善PSC患者的ALP。

原始出处:
Allegretti, Jessica R. et al. Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis. American Journal of Gastroenterology.2019.

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    2019-07-26 wjcjjian
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    2020-05-24 minzju5052
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628386, encodeId=5fc0162838611, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Tue Jul 16 09:26:00 CST 2019, time=2019-07-16, status=1, ipAttribution=)]
    2019-07-16 Homburg
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DCR:围手术期连续粪便钙卫蛋白水平对克罗恩病早期内镜复发的预测能力

围手术期的粪便钙网蛋白水平变化以及它是否预示早期术后复发内镜的克罗恩病是未知的。因此本项研究的目的是比较的围手术期粪便钙卫蛋白水平与术后3个月克罗恩病内镜复发的情况。

DDS:不同消化道肿瘤的患者粪便微生物组成也不同

我们都知道,栖息在人体肠道中的微生物生态系统构成了我们生理和新陈代谢的核心组成部分,它们参与着我们人体的健康和疾病的状态的改变。不同肠道微生物群的组成和活性的变化可导致免疫力下降,炎症的出现,甚至癌症的发生。因此,本项研究基于胃肠道肿瘤部位(GIT)比较来自不同位置的肿瘤的患者的粪便样品中肠道微生物群的组成和多样性,并评估细菌组合物对肿瘤发生的可能影响。

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