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Psychosom Med:抑郁会降低癌症患者生存期

2015-12-21 Seven L 译 MedSci原创

先前有研究表明抑郁与癌症患者死亡率具有一定关系。研究者对新近诊断的鳞状细胞口咽癌患者进行前瞻性研究,从放射治疗开始直到患者死亡或最后一次临床随访。 所有患者均进行了放疗和偶尔的化疗。校正肿瘤分期、治疗、并发症、吸烟、饮酒、人口统计学等因素后,评估自我报道的抑郁与整体生存期和复发的关系。研究者对平均年龄56岁的130名患者中位数随访了5年,其中83%是男性。研究期间发生了18例死亡和15例复发。研究

先前有研究表明抑郁与癌症患者死亡率具有一定关系。研究者对新近诊断的鳞状细胞口咽癌患者进行前瞻性研究,从放射治疗开始直到患者死亡或最后一次临床随访。

所有患者均进行了放疗和偶尔的化疗。校正肿瘤分期、治疗、并发症、吸烟、饮酒、人口统计学等因素后,评估自我报道的抑郁与整体生存期和复发的关系。

研究者对平均年龄56岁的130名患者中位数随访了5年,其中83%是男性。研究期间发生了18例死亡和15例复发。研究数据显示,自我报道的抑郁会减少总体生存时间(HR = 3.6, 95% CI = 1.2-10.8),增加复发风险(HR = 3.8, 95% CI = 1.2-12.2)。除此之外,吸烟也会增加疾病复发风险。

研究结果表明,对口咽癌患者进行抑郁筛查,并进行基于证据的治疗,会对其大大裨益。未来还需要更多的研究探究抑郁是否是该类患者预后的独立预测因素,以及阐明其中的生物学机制。

原始出处:

Shinn EH, Valentine A,et al.Depression and Oropharynx Cancer Outcome.Psychosom Med. 2015 Dec 3.


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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2015-12-27 wzf990214

    有意思

    0

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    2015-12-27 wzf990214

    赞一个

    0

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