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JCEM:不同表型糖尿病前期与2型糖尿病患者胰岛素抵抗与β细胞功能障碍的关联研究

2014-11-20 MedSci MedSci原创

研究背景: 使用HbA1c或血糖水平作为诊断依据诊断的糖尿病少有交叉,并且对于HbA1c诊断识别哪些病理生理缺陷仍然不明。 研究目的: 我们对不同表型亚分类的糖尿病前期和2型糖尿病患者的胰岛素敏感性及β细胞功能进行了检测并分析相关性。 研究设计: 我们开展了一项基于丹麦人群ADDITION-PRO研究的横断面研究(n=1713)。既往无糖尿病病史的受试者在接受检测后根

研究背景:

使用HbA1c或血糖水平作为诊断依据诊断的糖尿病少有交叉,并且对于HbA1c诊断识别哪些病理生理缺陷仍然不明。

研究目的:

我们对不同表型亚分类的糖尿病前期和2糖尿病患者的胰岛素敏感性及β细胞功能进行了检测并分析相关性。

研究设计:

我们开展了一项基于丹麦人群ADDITION-PRO研究的横断面研究(n=1713)。既往无糖尿病病史的受试者在接受检测后根据空腹或餐后两小时血糖或HbA1c水平,被分为糖尿病前期组和2型糖尿病组。此外,根据口服葡萄糖耐量试验(OGTT)过程中的血糖及胰岛素水平确定患者的胰岛素敏感性和胰岛素释放情况,并且计算处置指数。

研究结果:

与伴有餐后两小时血糖升高的患者相比,以空腹血糖诊断的糖尿病前期或2型糖尿病个体胰岛素绝对释放量降低(P≤0.01),而在摄入葡萄糖后表现出更高的胰岛素敏感性(P≤0.01),但两组处置指数相近(P≥0.36)。以HbA1c确诊的2型糖尿病或糖尿病前期患者表现为具有以血糖水平诊断个体的混合性病理生理缺陷,并且HbA1c水平正常者较血糖诊断标准下血糖正常者拥有更为严重的病理生理紊乱。

研究结论:

总体来说,以HbA1c诊断的糖尿病及糖尿病前期的个体拥有那些以血糖水平诊断个体混合的病理生理改变特征,但是经OGTT发现的病理生理改变及多样性在简单HbA1c标准下不能被发现。仍然需要后续纵向研究观察以空腹血糖、餐后两小时血糖或HbA1c作为诊断标准时患者疾病的进展和预后是否存在差异。

原始出处:

Kristine Færch, Nanna B. Johansen, Daniel R. Witte, Torsten Lauritzen, Marit E. Jørgensen, and Dorte Vistisen. Relationship between insulin resistance and beta cell dysfunction in subphenotypes of pre-diabetes and type 2 diabetes. JCEM, Nov 11, 2014.

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encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
    2015-03-05 smallant2015
  2. 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    2015-06-08 baoya
  3. 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encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
    2015-06-08 ljjj1053

    非常好非常好

    0

  4. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535110, encodeId=22dd1535110ba, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586779, encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
    2015-07-12 achengzhao
  5. [GetPortalCommentsPageByObjectIdResponse(id=1777494, encodeId=1d7f1e774947e, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 05 08:04:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749511, encodeId=6bcc1e49511e3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1777494, encodeId=1d7f1e774947e, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 05 08:04:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749511, encodeId=6bcc1e49511e3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1777494, encodeId=1d7f1e774947e, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 05 08:04:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749511, encodeId=6bcc1e49511e3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421012, encodeId=b19314210128a, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473842, encodeId=724214e3842f9, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, 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encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1777494, encodeId=1d7f1e774947e, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 05 08:04:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749511, encodeId=6bcc1e49511e3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1777494, encodeId=1d7f1e774947e, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 05 08:04:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749511, encodeId=6bcc1e49511e3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535110, encodeId=22dd1535110ba, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586779, encodeId=d3ef1586e79bd, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Sat Nov 22 12:04:00 CST 2014, time=2014-11-22, status=1, ipAttribution=)]
    2014-11-22 tastas
  10. 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