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J Urol：诊断因素代替前列腺癌活检

2016-01-08 佚名 生物谷

诊断因素代替前列腺癌活检
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图片来源：medicalxpress.com 近日，刊登于国际杂志The Journal of Urology上的一项研究论文中，来自纽约市斯隆凯特林癌症纪念中心的科学家们通过研究发现，初步诊断的特征或许可以帮助鉴别那些开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查，即特殊的诊断因子可以帮助患者避免进行前列腺癌的活组织检查。 研究人员Prassannah Satasivam博士

图片来源：medicalxpress.com

近日，刊登于国际杂志The Journal of Urology上的一项研究论文中，来自纽约市斯隆凯特林癌症纪念中心的科学家们通过研究发现，初步诊断的特征或许可以帮助鉴别那些开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查，即特殊的诊断因子可以帮助患者避免进行前列腺癌的活组织检查。

研究人员Prassannah Satasivam博士表示，我们对393名男性患者进行了研究，这些患者初步活组织检查结果为格里森分值6分；随后研究者评估了是否初步诊断参数可以帮助预测这些患者进行活组织检查的确认，这些初步诊断参数包括：前列腺特异性抗原密度、磁共振成像结果、阳性核心的百分比、阳性核心中的癌症百分比及总体的肿瘤长度等。

结果表明，11%的男性患有高等级的前列腺癌，在单变量分析中，所有的预测因素都和确认的活组织检查得到的高级别癌症明显相关；然而在多变量分析研究中研究者却发现，仅有前列腺特异性抗原密度和总体的肿瘤尺寸和高级别的前列腺癌相关。

最后研究者指出，利用新型模型来选择进行活组织检查确认的患者或许会为患者提供更高的净效益，而这明显比在所有患者中进行活组织检查确认要好得多；目前研究人员还希望通过后期更为深入地研究来阐明多种诊断因素如何帮助患者来避免不必要的活组织检查，从而为改善患者的生存质量及制定新的治疗前列腺癌治疗策略提供新的思路。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=64399, encodeId=b20864399ea, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160107/IMG568E5709267878353.jpg, createdBy=000a1677311, createdName=byong, createdTime=Mon Feb 15 23:40:00 CST 2016, time=2016-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55545, encodeId=6e495554550, content=开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 10 21:08:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277963, encodeId=264612e796358, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jan 10 00:11:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54652, encodeId=f85554652d5, content=好东西，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 19:24:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54608, encodeId=863e5460863, content=无创检查最终会取代创伤性检查。, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Fri Jan 08 15:19:00 CST 2016, time=2016-01-08, status=1, ipAttribution=)]
    2016-02-15 byong

    值得学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=64399, encodeId=b20864399ea, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160107/IMG568E5709267878353.jpg, createdBy=000a1677311, createdName=byong, createdTime=Mon Feb 15 23:40:00 CST 2016, time=2016-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55545, encodeId=6e495554550, content=开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 10 21:08:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277963, encodeId=264612e796358, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jan 10 00:11:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54652, encodeId=f85554652d5, content=好东西，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 19:24:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54608, encodeId=863e5460863, content=无创检查最终会取代创伤性检查。, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Fri Jan 08 15:19:00 CST 2016, time=2016-01-08, status=1, ipAttribution=)]
    2016-01-10 jetleo

    开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=64399, encodeId=b20864399ea, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160107/IMG568E5709267878353.jpg, createdBy=000a1677311, createdName=byong, createdTime=Mon Feb 15 23:40:00 CST 2016, time=2016-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55545, encodeId=6e495554550, content=开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 10 21:08:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277963, encodeId=264612e796358, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jan 10 00:11:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54652, encodeId=f85554652d5, content=好东西，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 19:24:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54608, encodeId=863e5460863, content=无创检查最终会取代创伤性检查。, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Fri Jan 08 15:19:00 CST 2016, time=2016-01-08, status=1, ipAttribution=)]
    2016-01-10 smlt2008

    #活检#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=64399, encodeId=b20864399ea, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160107/IMG568E5709267878353.jpg, createdBy=000a1677311, createdName=byong, createdTime=Mon Feb 15 23:40:00 CST 2016, time=2016-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55545, encodeId=6e495554550, content=开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 10 21:08:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277963, encodeId=264612e796358, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jan 10 00:11:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54652, encodeId=f85554652d5, content=好东西，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 19:24:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54608, encodeId=863e5460863, content=无创检查最终会取代创伤性检查。, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Fri Jan 08 15:19:00 CST 2016, time=2016-01-08, status=1, ipAttribution=)]
    2016-01-08 andruhn

    好东西，学习了！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=64399, encodeId=b20864399ea, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160107/IMG568E5709267878353.jpg, createdBy=000a1677311, createdName=byong, createdTime=Mon Feb 15 23:40:00 CST 2016, time=2016-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55545, encodeId=6e495554550, content=开始采取积极监测的男性是否可以避免进行前列腺癌活组织检查, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Jan 10 21:08:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277963, encodeId=264612e796358, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sun Jan 10 00:11:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54652, encodeId=f85554652d5, content=好东西，学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69b61619007, createdName=andruhn, createdTime=Fri Jan 08 19:24:00 CST 2016, time=2016-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54608, encodeId=863e5460863, content=无创检查最终会取代创伤性检查。, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Fri Jan 08 15:19:00 CST 2016, time=2016-01-08, status=1, ipAttribution=)]
    2016-01-08 sword20000

    无创检查最终会取代创伤性检查。

    0

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