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Sci Rep：rhBMP-2和DMOG联合应用可显著改善临界骨缺损中的骨再生

2018-01-23 MedSci MedSci原创

关注

在骨重塑中，骨生成与血管生成密切相关。使用多功能生物活性材料进行骨组织工程是一种有前途的技术，它具有同时刺激骨生成和血管生成以修复骨缺损的能力。本研究中，研究人员制备了中孔生物活性玻璃（MBG）掺杂的聚（3-羟基丁酸酯-共-3-羟基己酸酯）（PHBHHx）复合支架作为递送载体。将两种生物活性分子，二甲基草酰甘氨酸（DMOG），一种小分子血管生成药物，和重组人骨形态发生蛋白-2（rhBMP-2）（骨

在骨重塑中，骨生成与血管生成密切相关。使用多功能生物活性材料进行骨组织工程是一种有前途的技术，它具有同时刺激骨生成和血管生成以修复骨缺损的能力。本研究中，研究人员制备了中孔生物活性玻璃（MBG）掺杂的聚（3-羟基丁酸酯-共-3-羟基己酸酯）（PHBHHx）复合支架作为递送载体。

将两种生物活性分子，二甲基草酰甘氨酸（DMOG），一种小分子血管生成药物，和重组人骨形态发生蛋白-2（rhBMP-2）（骨诱导生长因子）共同掺入支架中。采用实时定量聚合酶链反应和免疫印迹技术研究复合支架释放的DMOG和rhBMP-2对hBMSCs成骨分化和血管生成分化的协同作用。此外，使用显微计算机断层扫描、组织学分析、Microfil灌注、荧光标记和免疫组织化学分析，进行体内研究以观察大鼠中临界尺寸骨缺陷的骨再生和血管形成。

结果显示，在MBG-PHBHHx支架中释放的DMOG和rhBMP-2确实对hBMSCs的成骨和血管生成分化具有协同作用。此外，DMOG和rhBMP-2联合使用可明显增加大鼠颅骨骨缺损的骨生成量和新血管形成。

综上所述，该研究结果表明，rhBMP-2和DMOG联合给药可显著改善临界骨缺损的骨再生。

原始出处：

Qi X, Liu Y, et al., Synergistic effects of dimethyloxallyl glycine and recombinant human bone morphogenetic protein-2 on repair of critical-sized bone defects in rats. Sci Rep. 2017 Feb 23;7:42820. doi: 10.1038/srep42820.

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    2018-03-11 ms5187542471278033

    #rhBMP#

    0

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    2018-09-20 12498f17m73暂无昵称

    #BMP-2#

    0

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    2018-12-01 s_pl2017

    #联合应用#

    0

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    2018-06-23 HNYYM

    #BMP#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1793335, encodeId=cb1c1e9333508, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Mar 11 23:14:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642647, encodeId=2eb6164264eb1, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Thu Sep 20 20:14:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684170, encodeId=0cef16841e0f0, content=<a href='/topic/show?id=7425806967a' target=_blank style='color:#2F92EE;'>#联合应用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80696, encryptionId=7425806967a, topicName=联合应用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091d28056243, createdName=s_pl2017, createdTime=Sat Dec 01 15:14:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634020, encodeId=997716340205e, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Sat Jun 23 01:14:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419251, encodeId=0f5f1419251d8, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472103, encodeId=b12214e210379, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585376, encodeId=a7f515853e62e, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-25 lfcmxl

    #骨缺损#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1793335, encodeId=cb1c1e9333508, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Mar 11 23:14:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642647, encodeId=2eb6164264eb1, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Thu Sep 20 20:14:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684170, encodeId=0cef16841e0f0, content=<a href='/topic/show?id=7425806967a' target=_blank style='color:#2F92EE;'>#联合应用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80696, encryptionId=7425806967a, topicName=联合应用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091d28056243, createdName=s_pl2017, createdTime=Sat Dec 01 15:14:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634020, encodeId=997716340205e, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Sat Jun 23 01:14:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419251, encodeId=0f5f1419251d8, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472103, encodeId=b12214e210379, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585376, encodeId=a7f515853e62e, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-25 lsj630

    #骨再生#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1793335, encodeId=cb1c1e9333508, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Mar 11 23:14:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642647, encodeId=2eb6164264eb1, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Thu Sep 20 20:14:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684170, encodeId=0cef16841e0f0, content=<a href='/topic/show?id=7425806967a' target=_blank style='color:#2F92EE;'>#联合应用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80696, encryptionId=7425806967a, topicName=联合应用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091d28056243, createdName=s_pl2017, createdTime=Sat Dec 01 15:14:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634020, encodeId=997716340205e, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Sat Jun 23 01:14:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419251, encodeId=0f5f1419251d8, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472103, encodeId=b12214e210379, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585376, encodeId=a7f515853e62e, content=<a href='/topic/show?id=2e681208016' target=_blank style='color:#2F92EE;'>#MOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12080, encryptionId=2e681208016, topicName=MOG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a85417178370, createdName=Boyinsh, createdTime=Thu Jan 25 11:14:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-25 Boyinsh

    #MOG#

    0

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