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Sci Rep：研究发现心梗诱导心肌纤维化的相关LncRNA

2017-09-02 MedSci MedSci原创

lncRNA心梗心肌纤维化
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研究发现一种称之为心肌梗死相关转录（MIAT）的长非编码RNA（lncRNA）可用于预测心肌梗死（MI）的风险。本研究旨在探讨MIAT在调节心脏纤维化过程中的病理生理作用。研究人员建立了MI小鼠模型，结果发现MIAT显著上调，并伴有心肌间质纤维化。MI中MIAT上调伴随着一些纤维化相关因子的下调：miR-24下调，Furin 和 TGF-β1上调。最值得注意的是，通过siRNA敲除内源MIAT可减

研究发现一种称之为心肌梗死相关转录（MIAT）的长非编码RNA（lncRNA）可用于预测心肌梗死（MI）的风险。本研究旨在探讨MIAT在调节心脏纤维化过程中的病理生理作用。

研究人员建立了MI小鼠模型，结果发现MIAT显著上调，并伴有心肌间质纤维化。MI中MIAT上调伴随着一些纤维化相关因子的下调：miR-24下调，Furin 和 TGF-β1上调。最值得注意的是，通过siRNA敲除内源MIAT可减少心肌纤维化，并改善心功能，恢复纤维化相关因子的低表达。使用血清或血管紧张素II治疗心脏成纤维细胞，可持续发现MIAT上调和miR-24下调。这些变化促进成纤维细胞的增殖和胶原蛋白的积累，而通过siRNA敲除MIAT或过表达miR-24可抑制纤维化。

总之，该研究结果确定了MIAT作为心脏纤维化的促纤维化lncRNA，并揭示了MIAT在心肌梗死发病机制中的作用。这些研究发现还表明MIAT水平正常化或是治疗心梗诱导的心肌纤维化的潜在疗法，且与心功能相关。

原始出处：

Xuefeng Qu, Yue Du, et al., MIAT Is a Pro-fibrotic Long Non-coding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium. Sci Rep. 2017; 7: 42657. Published online 2017 Feb 15. doi: 10.1038/srep42657.

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    2018-07-31 okhuali

    #肌纤维#

    0

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    2018-06-20 hanhaisha2020

    #研究发现#

    0

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    2018-05-02 yanjie6253_56072842

    #CRN#

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 08 09:06:36 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241117, encodeId=26d824111e1a, content=文章不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Wed Sep 06 19:16:32 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240195, encodeId=2910240195b9, content=文章不错.赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 04 06:04:51 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301861, encodeId=0fcb130186130, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Mon Sep 04 06:04:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239837, encodeId=bfd923983ef9, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Sep 02 23:12:22 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239820, encodeId=ab5f239820c7, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Sep 02 21:42:46 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239794, encodeId=632f239e943e, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-08 1e10c84am36(暂无匿称)

    文章不错.值得分享

    0

  5. 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likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Sep 02 23:12:22 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239820, encodeId=ab5f239820c7, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Sep 02 21:42:46 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239794, encodeId=632f239e943e, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-06 1e1263e3m20(暂无匿称)

    文章不错学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2078020, encodeId=4d8e20e802085, content=<a href='/topic/show?id=8a8580960a5' target=_blank style='color:#2F92EE;'>#肌纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80960, encryptionId=8a8580960a5, topicName=肌纤维)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Tue Jul 31 13:04:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753272, encodeId=1ae41e532722a, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, 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likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Sep 02 23:12:22 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239820, encodeId=ab5f239820c7, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Sep 02 21:42:46 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239794, encodeId=632f239e943e, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-04 1e10c84am36(暂无匿称)

    文章不错.赞赞赞

    0

  7. 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likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Sep 02 23:12:22 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239820, encodeId=ab5f239820c7, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Sep 02 21:42:46 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239794, encodeId=632f239e943e, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-04 xzw113

    #lncRNA#

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-02 往日如昨

    继续学习中谢谢

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-02 1e0ece0dm09(暂无匿称)

    谢谢

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Sep 02 19:36:15 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-02 131****1460

    学习了受益匪浅.

    0

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人类基因组计划揭示人基因组中有30亿个碱基对，其中1.5%能够编码蛋白质，98.5%是非蛋白质编码基因，这些基因序列一度被认为是垃圾基因。然而随后的ENCODE计划表明，大约75%的人类基因组能被转录成RNAs，当中74%是非蛋白编码RNA（ncRNAs）。随着基因组学和生物信息学的发展，尤其是高通量测序技术的大量应用，科学家发现了越来越多的非蛋白编码的转录单元（即非编码RNA，ncRNAs），

我国科学家发现裸鼹鼠的LncRNA抗癌特性

近日，中国科学院昆明动物研究所孔庆鹏课题组研究发现裸鼹鼠的抗癌特性与长链非编码RNA密切相关，相关成果发表在《表观遗传学与染色质》期刊上。据了解，裸鼹鼠是啮齿类动物中名副其实的长寿之星，其寿命可长达30年，而一般小鼠及大鼠的寿命仅有2~3年。此外，裸鼹鼠还具有天然的抗癌特性，因此裸鼹鼠在长寿和肿瘤研究领域受到极其广泛的关注。长链非编码RNA（LncRNA）被定义为长度大于200bp而不具备编码蛋白

Nature：令黑色素瘤成瘾的物质被发现，可能是重大突破

与根特大学（UGent）研究人员合作，来自鲁汶大学（KU Leuven）的VIB科学家们揭示了恶性黑色素瘤与非编码RNA基因SAMMSON之间不同寻常的联系。SAMMSON基因会在人类恶性黑色素瘤中特异性表达，而且引人注目的是，这种凶险皮肤癌的生长高度依赖于这种基因。研究结论可能为改进诊断工具和皮肤癌的治疗铺平道路。这项最新发表于《Nature》期刊的研究由Jean-Christophe Mari

Anal Cell Pathol：研究阐明 MIR4697HG在卵巢癌生长及转移中的作用

卵巢癌是世界上最常见的三大妇科恶性肿瘤之一。由于治疗策略的限制，这种恶性肿瘤患者的预后仍然很差。本研究中，研究人员探究了了一种长链非编码RNA (MIR4697HG)在卵巢癌细胞生长与转移中的作用。结果表明，癌组织中MIR4697HG的转录水平较癌旁组织增加了一倍。卵巢癌细胞系中MIR4697HG的表达不同，OVCAR3 和 SKOV3细胞中表达水平最高。通过特定的shRNA敲除MIR4697HG

Nat Commun：王红阳课题组等揭示与肝癌发生和转移相关的新型长链非编码RNA基因

近期，国际学术权威刊物自然出版集团旗下子刊《Nature Communications》杂志在线发表了清华大学生命科学学院鲁志课题组、信息学院与医学院张奇伟课题组以及上海东方肝胆医院王红阳院士课题组合作发表题为Recurrently deregulated lncRNAs in hepatocellular carcinoma的研究论文，论文通过基因组学和生物信息学方法揭示了在肝癌发生发展及转移过

SCI REP：LINC00152的过度表达与患者生存率不佳相关，并且敲低LINC00152会损害肺癌细胞增殖

我们对从3个独立队列中筛选的461例肺腺癌和156例正常肺组织，进行RNA测序分析，以揭示肺癌中的异常调节的lncRNA。我们发现，与和其相邻的正常组织相比，LINC00152在肺肿瘤严重的过度表达。我们的研究表明LINC00152在肺肿瘤生长中起重要作用，并且是一种潜在的诊断/预后标志物。LINC00152在靶蛋白调控中的进一步表征可能为肺癌提供了新的治疗靶点。

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