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JACC：“代谢健康肥胖”再遭质疑

2014-05-06 伊文 中华医学会糖尿病学分会

代谢综合征糖尿病
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既往有专家认为，不伴代谢异常的肥胖是“代谢健康肥胖”。近年来，陆续有研究质疑这一观点。近日，一项韩国研究再次提出质疑，该研究显示，与体重正常者相比，无心血管病的成年肥胖患者冠脉钙化风险明显升高。 该研究入选14 828例无心血管病的“代谢健康”(不存在代谢综合征及其组成成分且稳态模型胰岛素抵抗指数<2.5)成年受试者，平均体质指数23 kg/m2。研究者发现，代谢健康肥胖受试者中冠脉钙

既往有专家认为，不伴代谢异常的肥胖是“代谢健康肥胖”。近年来，陆续有研究质疑这一观点。近日，一项韩国研究再次提出质疑，该研究显示，与体重正常者相比，无心血管病的成年肥胖患者冠脉钙化风险明显升高。

该研究入选14 828例无心血管病的“代谢健康”(不存在代谢综合征及其组成成分且稳态模型胰岛素抵抗指数<2.5)成年受试者，平均体质指数23 kg/m2。研究者发现，代谢健康肥胖受试者中冠脉钙化发生率明显高于体重正常者。多变量分析表明，即便校正代谢危险因素，冠脉钙化评分较高与肥胖仍显著相关。

原始出处：


Chang Y1, Kim BK2, Yun KE2, Cho J3, Zhang Y4, Rampal S5, Zhao D4, Jung HS2, Choi Y2, Ahn J2, Lima JA6, Shin H7, Guallar E4, Ryu S8.Metabolically healthy obesity and coronary artery calcification.J Am Coll Cardiol. 2014 Apr 17. pii: S0735-1097(14)02051-8. doi: 10.1016/j.jacc.2014.03.042. [Epub ahead of print]

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    2014-07-28 hbwxf

    #JACC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1853280, encodeId=d4211853280c5, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jul 28 15:02:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735044, encodeId=b0581e3504422, content=<a href='/topic/show?id=9aa5923e176' target=_blank style='color:#2F92EE;'>#质疑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92371, encryptionId=9aa5923e176, topicName=质疑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3033872914, createdName=saikp, createdTime=Sat Mar 07 18:02:00 CST 2015, time=2015-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324931, encodeId=377313249310a, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu May 08 05:02:00 CST 2014, time=2014-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571380, encodeId=705c15e138032, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Thu May 08 05:02:00 CST 2014, time=2014-05-08, status=1, ipAttribution=)]
    2015-03-07 saikp

    #质疑#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1853280, encodeId=d4211853280c5, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jul 28 15:02:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735044, encodeId=b0581e3504422, content=<a href='/topic/show?id=9aa5923e176' target=_blank style='color:#2F92EE;'>#质疑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92371, encryptionId=9aa5923e176, topicName=质疑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3033872914, createdName=saikp, createdTime=Sat Mar 07 18:02:00 CST 2015, time=2015-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324931, encodeId=377313249310a, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu May 08 05:02:00 CST 2014, time=2014-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571380, encodeId=705c15e138032, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Thu May 08 05:02:00 CST 2014, time=2014-05-08, status=1, ipAttribution=)]
    2014-05-08 12498568m50暂无昵称

    #ACC#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1853280, encodeId=d4211853280c5, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jul 28 15:02:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735044, encodeId=b0581e3504422, content=<a href='/topic/show?id=9aa5923e176' target=_blank style='color:#2F92EE;'>#质疑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92371, encryptionId=9aa5923e176, topicName=质疑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3033872914, createdName=saikp, createdTime=Sat Mar 07 18:02:00 CST 2015, time=2015-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324931, encodeId=377313249310a, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu May 08 05:02:00 CST 2014, time=2014-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571380, encodeId=705c15e138032, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Thu May 08 05:02:00 CST 2014, time=2014-05-08, status=1, ipAttribution=)]
    2014-05-08 宋威

    #代谢健康#

    0

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