Baidu
map

JAMA Netw Open:三手烟改变人鼻上皮细胞的基因表达

2019-06-30 佚名 中国生物技术网

由美国加州大学河滨分校(UCR)的科学家领导的一个研究团队发现,三手烟会通过给呼吸系统的上皮细胞施压来损害它们。该研究已于6月28日发表在《JAMA Network Open》上。

众所周知,一手烟和二手烟,会严重危害健康,是肺癌的主要原因。现在,一项新研究告诉我们,三手烟对健康的危害也正在进行时......

三手烟是当呼出的烟和从燃烧香烟散发出来的烟尘落在衣服、头发、家具和汽车等表面时产生的。它不是严格意义上的吸烟,而是指吸烟后的残留物。

由美国加州大学河滨分校(UCR)的科学家领导的一个研究团队发现,三手烟会通过给呼吸系统的上皮细胞施压来损害它们。该研究已于6月28日发表在《JAMA Network Open》上。

研究负责人、UCR干细胞中心主任和分子、细胞和系统生物学系教授Prue Talbot说:“我们的数据表明,人体细胞确实会受到三手烟的影响。三手烟对健康的影响已经在培养的细胞和动物模型上进行了研究,但这是第一次显示其对人类基因表达直接影响的研究。”

该研究第一作者、Talbot实验室的研究生Giovanna Pozuelos说,“这些物质会重新回到大气中,不吸烟的人会不情愿地吸入。但到目前为止,它还没有得到广泛的研究,这或许可以解释为什么没有任何法律法规保护非吸烟者免受其害。”

在这项研究中,研究人员从加州大学旧金山分校的实验室环境中采集四名女性健康非吸烟者的鼻黏膜刮片样本,这些人无慢性病史。她们被暴露于三手烟实验环境三个小时。研究人员随后从样本中提取足够数量的RNA,并通过RNA测序鉴定出过表达或低表达的基因。他们发现382个基因明显过表达,另外7个基因表达不足。然后他们确定了受这些基因影响的途径。



《JAMA Network Open》

Pozuelos说:“健康的非吸烟者在吸入三小时后,鼻上皮细胞的基因表达发生了显著变化。它改变了与氧化应激相关的途径,氧化应激可能会损害DNA,癌症是一个潜在的长期后果。接触三手烟三个小时不太可能导致癌症,但如果有人住在公寓或家里,或经常开车到有这种情况的地方,就会对健康产生影响。”

由于鼻上皮细胞的基因表达与支气管的相似,研究人员指出,他们的数据与呼吸系统更深层的细胞相关。在他们研究的样本中,研究人员发现,短暂的三手烟暴露会影响线粒体的活性。线粒体是细胞能量工厂。如果不加以控制,观察到的效应将导致细胞死亡。

Pozuelos解释说,研究团队将重点放在鼻上皮,因为鼻腔是三手烟进入人肺的一种途径。另一种常见的暴露途径是通过皮肤,研究人员还未对此进行研究,但计划在未来进行。

目前,研究人员已经与加州大学圣迭戈和辛辛那提分校的研究团队合作,研究长期接触三手烟的情况。

Talbot说:“许多人不知道三手烟是什么。我们这项研究能够提高人们对这一潜在健康危害的认识。许多烟民认为,我只是在户外吸烟,这样我的家人在家里就不会接触到。但吸烟者会将尼古丁等化学物质留在衣服上带回室内。重要的是,人们要认识到,三手烟是真实的,并具有潜在的危害性。”

原始出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1734146, encodeId=9dc01e3414632, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Dec 27 10:21:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728034, encodeId=52fa1e2803460, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Nov 25 09:21:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348101, encodeId=d5a5134810121, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530348, encodeId=248d153034871, content=<a href='/topic/show?id=19c11965329' target=_blank style='color:#2F92EE;'>#三手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19653, encryptionId=19c11965329, topicName=三手烟)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3c12090966, createdName=changjitao2013, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533896, encodeId=0558153389653, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-12-27 canlab
  2. [GetPortalCommentsPageByObjectIdResponse(id=1734146, encodeId=9dc01e3414632, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Dec 27 10:21:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728034, encodeId=52fa1e2803460, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Nov 25 09:21:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348101, encodeId=d5a5134810121, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530348, encodeId=248d153034871, content=<a href='/topic/show?id=19c11965329' target=_blank style='color:#2F92EE;'>#三手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19653, encryptionId=19c11965329, topicName=三手烟)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3c12090966, createdName=changjitao2013, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533896, encodeId=0558153389653, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-11-25 feather89
  3. [GetPortalCommentsPageByObjectIdResponse(id=1734146, encodeId=9dc01e3414632, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Dec 27 10:21:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728034, encodeId=52fa1e2803460, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Nov 25 09:21:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348101, encodeId=d5a5134810121, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530348, encodeId=248d153034871, content=<a href='/topic/show?id=19c11965329' target=_blank style='color:#2F92EE;'>#三手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19653, encryptionId=19c11965329, topicName=三手烟)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3c12090966, createdName=changjitao2013, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533896, encodeId=0558153389653, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1734146, encodeId=9dc01e3414632, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Dec 27 10:21:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728034, encodeId=52fa1e2803460, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Nov 25 09:21:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348101, encodeId=d5a5134810121, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530348, encodeId=248d153034871, content=<a href='/topic/show?id=19c11965329' target=_blank style='color:#2F92EE;'>#三手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19653, encryptionId=19c11965329, topicName=三手烟)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3c12090966, createdName=changjitao2013, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533896, encodeId=0558153389653, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1734146, encodeId=9dc01e3414632, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Dec 27 10:21:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728034, encodeId=52fa1e2803460, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Nov 25 09:21:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348101, encodeId=d5a5134810121, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530348, encodeId=248d153034871, content=<a href='/topic/show?id=19c11965329' target=_blank style='color:#2F92EE;'>#三手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19653, encryptionId=19c11965329, topicName=三手烟)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3c12090966, createdName=changjitao2013, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533896, encodeId=0558153389653, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Jul 02 08:21:00 CST 2019, time=2019-07-02, status=1, ipAttribution=)]

相关资讯

烟草危害:三手烟影响体重和免疫系统

美国能源部下属劳伦斯伯克利国家实验室(Berkeley Lab)的研究人员的一项研究揭示了三手烟的危害:烟草烟雾留下的粘性残留物与烧坏的家具或褪漆的墙壁相比会对人体造成更多更为严重的危害,暴露于三手烟会对体重和细胞发育产生不容忽视的生物学效应,进而损害人体的健康。

“隐形杀手”三手烟:伤脑又伤肝,接触越久危害越大

三手烟(thirdhand-smoke)指的是在吸烟者“吞云吐雾”后,留存在室内家居陈设表面的残留物及其发生化学变化后产生的有害物质。惨遭三手烟荼毒的往往是那些没有吸烟习惯,仅仅是与家具、汽车等有过接触的人,尤其是儿童。大多数人可能仍旧低估或是不相信三手烟对健康的危害,但过往一些在小鼠身上的实验显示,三手烟接触可能导致亢奋、肝肺损伤,甚至2型糖尿病、伤口愈合并发症等问题。毫无疑问,三手烟接触问题急

动物实验显示“三手烟”导致肝损伤和糖尿病

新华社北京9月18日电 美国科学家通过动物实验发现,通过衣物、家具等接触“三手烟”,会增加实验鼠出现肝损伤和糖尿病等疾病的风险。

Clin Sci:三手烟的危害

加利福尼亚大学河滨分校的研究人员发现,接触三手烟(THS)即便一个月后对人们的健康仍有有重要影响,并且随着时间的推移,这种影响越来越严重。

Clin Sci:三手烟增加肺癌风险

美国能源部劳伦斯伯克利国家实验室公布的一项最新研究说,三手烟会增加小鼠患肺癌的风险。

Tobacco Control:吸烟家庭的新忧患:“三手烟”

迈克尔·米勒(Michael Miller)和许多吸烟者一样,为了保护他的儿女免受香烟烟雾的影响。 他都在外面抽烟。

Baidu
map
Baidu
map
Baidu
map