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Cell Reports:利用肠道激素酪酪肽或可有效治疗2型糖尿病

2016-05-23 MedSci MedSci原创

Cell Reports:利用肠道激素酪酪肽或可有效治疗2型糖尿病据发表于Cell Reports 的一项新的研究表明,可抑制食欲的一种肠道激素——酪酪肽(PYY),还可影响胰岛的功能,从而或为2型糖尿病的治疗提供新的有效治疗方法。“许多病态肥胖的患者同时也是2型糖尿病患者,” Magnus Kringstad Olsen,来自挪威科学技术大学癌症研究和分子医学系,在新闻发布会上说道。肥胖患者接受

Cell Reports:利用肠道激素酪酪肽或可有效治疗2型糖尿病

据发表于Cell Reports 的一项新的研究表明,可抑制食欲的一种肠道激素——酪酪肽(PYY),还可影响胰岛的功能,从而或为2型糖尿病的治疗提供新的有效治疗方法。

“许多病态肥胖的患者同时也是2型糖尿病患者,” Magnus Kringstad Olsen,来自挪威科学技术大学癌症研究和分子医学系,在新闻发布会上说道。

肥胖患者接受减肥术后往往会改善其糖尿病的状态,这或是由于胰高血糖素样肽—1(GLP-1,抑制食欲的一种激素)分泌水平所致。而这里,研究人员发现另一种激素——PYY,或可产生与GLP-1类似的效果。

补充:

肠道衍生激素酪酪肽(PYY)属胰多肽家族成员,由于它能使机体产生饱感、减少摄食和体重而为人们所知。PYY在消化道生理调节过程中起重要作用,外周作用和中枢作用涉及不同受体,其机制相当复杂。PYY3-36已经被列为治疗肥胖症的有效途径。临床使用的局限性是由于它较短的半衰期而且需要同安泰乐一起注射。

PYY的功能主要有:抑制空肠和结肠的运动以及肠道内的血管收缩;调节机体的摄食行为;抑制胃酸分泌;抑制胰岛素的分泌。

原始出处:

PYY may help reduce burden of type 2 diabetes. Healio, May 22, 2016.

Ramracheya RD, et al. PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery. Cell Reports. 2016;doi:10.1016/j.celrep.2016.03.091.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=808277, encodeId=74228082e7d4, content=最近正在找相关文章,文章很不错👍️, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/fe2a2fd587724dd2ba901218e5148c31/9d13e51cd06f4c4fba964ab2baecd3aa.jpg, createdBy=45a55402946, createdName=关公面前耍柳叶刀, createdTime=Wed Aug 12 22:40:50 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869387, encodeId=ecf8186938e56, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Feb 18 12:13:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88166, encodeId=eef3881669f, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:45:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959644, encodeId=ded31959644c5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Sep 30 09:13:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619426, encodeId=9a751619426bc, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed May 25 01:13:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86914, encodeId=e61c86914e3, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:09:00 CST 2016, time=2016-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86913, encodeId=05058691338, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:08:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2020-08-12 关公面前耍柳叶刀

    最近正在找相关文章,文章很不错👍️

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=808277, encodeId=74228082e7d4, content=最近正在找相关文章,文章很不错👍️, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/fe2a2fd587724dd2ba901218e5148c31/9d13e51cd06f4c4fba964ab2baecd3aa.jpg, createdBy=45a55402946, createdName=关公面前耍柳叶刀, createdTime=Wed Aug 12 22:40:50 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869387, encodeId=ecf8186938e56, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Feb 18 12:13:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88166, encodeId=eef3881669f, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:45:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959644, encodeId=ded31959644c5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Sep 30 09:13:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619426, encodeId=9a751619426bc, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed May 25 01:13:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86914, encodeId=e61c86914e3, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:09:00 CST 2016, time=2016-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86913, encodeId=05058691338, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:08:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=808277, encodeId=74228082e7d4, content=最近正在找相关文章,文章很不错👍️, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/fe2a2fd587724dd2ba901218e5148c31/9d13e51cd06f4c4fba964ab2baecd3aa.jpg, createdBy=45a55402946, createdName=关公面前耍柳叶刀, createdTime=Wed Aug 12 22:40:50 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869387, encodeId=ecf8186938e56, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Feb 18 12:13:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88166, encodeId=eef3881669f, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:45:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959644, encodeId=ded31959644c5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Sep 30 09:13:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619426, encodeId=9a751619426bc, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed May 25 01:13:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86914, encodeId=e61c86914e3, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:09:00 CST 2016, time=2016-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86913, encodeId=05058691338, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:08:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-06-02 沉心多思

    好文章,得多学习了!

    0

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    2016-09-30 维他命
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  6. [GetPortalCommentsPageByObjectIdResponse(id=808277, encodeId=74228082e7d4, content=最近正在找相关文章,文章很不错👍️, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/fe2a2fd587724dd2ba901218e5148c31/9d13e51cd06f4c4fba964ab2baecd3aa.jpg, createdBy=45a55402946, createdName=关公面前耍柳叶刀, createdTime=Wed Aug 12 22:40:50 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869387, encodeId=ecf8186938e56, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Feb 18 12:13:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88166, encodeId=eef3881669f, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:45:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959644, encodeId=ded31959644c5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Sep 30 09:13:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619426, encodeId=9a751619426bc, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed May 25 01:13:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86914, encodeId=e61c86914e3, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:09:00 CST 2016, time=2016-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86913, encodeId=05058691338, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:08:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-05-24 medscc

    嗯嗯

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=808277, encodeId=74228082e7d4, content=最近正在找相关文章,文章很不错👍️, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/fe2a2fd587724dd2ba901218e5148c31/9d13e51cd06f4c4fba964ab2baecd3aa.jpg, createdBy=45a55402946, createdName=关公面前耍柳叶刀, createdTime=Wed Aug 12 22:40:50 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869387, encodeId=ecf8186938e56, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Feb 18 12:13:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88166, encodeId=eef3881669f, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:45:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959644, encodeId=ded31959644c5, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Sep 30 09:13:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619426, encodeId=9a751619426bc, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed May 25 01:13:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86914, encodeId=e61c86914e3, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:09:00 CST 2016, time=2016-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86913, encodeId=05058691338, content=赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c891611001, createdName=medscc, createdTime=Tue May 24 11:08:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-05-24 medscc

    赚积分

    0

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