Baidu
map

Nat Cell Biol:黑色素瘤致病因子Sox10或有助于恶性胎记的治疗

2012-07-19 张笑 中国科学报

最新的《自然—细胞生物学》Nature Cell Biology上刊登一项研究称,科学家发现了一种因子,与先天性巨痣及其引起的黑色素瘤等出生胎记的形成和存在有着密切联系。该发现或能有助于开发针对恶性胎记的治疗新方法。 Olga Shakhova, Lukas Sommer等人对患有黑色素瘤的小鼠模型进行研究,该小鼠的黑色素瘤中含有已知的突变促进因子Nras,但缺少INK4a这种在人体黑色素瘤中并

最新的《自然—细胞生物学》Nature Cell Biology上刊登一项研究称,科学家发现了一种因子,与先天性巨痣及其引起的黑色素瘤等出生胎记的形成和存在有着密切联系。该发现或能有助于开发针对恶性胎记的治疗新方法。

Olga Shakhova, Lukas Sommer等人对患有黑色素瘤的小鼠模型进行研究,该小鼠的黑色素瘤中含有已知的突变促进因子Nras,但缺少INK4a这种在人体黑色素瘤中并不活跃的因子。研究人员发现该小鼠模型和患有先天性巨痣以及黑色素瘤的人体具有显著的相似性。他们接着发现在小鼠和人身上获得的黑色素瘤和巨痣的样本中,一种名为Sox10的因子均含有较高的水平含量,先前研究已证明Sox10是神经嵴干细胞转化形成皮肤色素细胞的发育过程所必需的。研究人员进一步发现通过抑制神经嵴干细胞并阻断细胞的增殖和存活,可降低Sox10的水平含量,从而阻止黑色素瘤的形成。

由此研究人员得出结论:Sox10在先天性巨痣和黑色素瘤的形成和存在方面起着关键作用。这为开发出针对入侵性皮肤癌的治疗方法提供潜在的依据。

doi:10.1038/ncb2535
PMC:
PMID:

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

Olga Shakhova,1 Daniel Zingg,1 Simon M. Schaefer,1 Lisette Hari,1 Gianluca Civenni,1 Jacqueline Blunschi,1 Stéphanie Claudinot,2 Michal Okoniewski,3 Friedrich Beermann,4 Daniela Mihic-Probst,5 Holger Moch,5 Michael Wegner,6 Reinhard Dummer,7 Yann Barrandon,2 Paolo Cinelli8, 9 & Lukas Sommer1

Giant congenital naevi are pigmented childhood lesions that frequently lead to melanoma, the most aggressive skin cancer. The mechanisms underlying this malignancy are largely unknown, and there are no effective therapies. Here we describe a mouse model for giant congenital naevi and show that naevi and melanoma prominently express Sox10,…

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (9)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
    2012-12-02 sunylz
  4. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
    2013-06-18 liye789132251
  5. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
    2013-05-06 周虎
  6. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
    2012-07-21 维他命
  7. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
    2013-04-11 sunylz
  8. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1766799, encodeId=55bb1e6679938, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat May 11 19:11:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868566, encodeId=d791186856649, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Apr 11 05:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916913, encodeId=8da7191691333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 02 01:11:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879317, encodeId=8ee018e931705, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jun 18 01:11:00 CST 2013, time=2013-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755492, encodeId=a2851e5549227, content=<a href='/topic/show?id=186616562dd' target=_blank style='color:#2F92EE;'>#Sox10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16562, encryptionId=186616562dd, topicName=Sox10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11c236925356, createdName=周虎, createdTime=Mon May 06 18:11:00 CST 2013, time=2013-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958798, encodeId=7c9f1958e9833, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jul 21 11:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680208, encodeId=c5c51680208ad, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Apr 11 14:11:00 CST 2013, time=2013-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558628, encodeId=2f85155862809, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564637, encodeId=df27156463ed5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Jul 21 02:11:00 CST 2012, time=2012-07-21, status=1, ipAttribution=)]

相关资讯

ASCO 2012:两大新药治疗BRAF突变黑色素瘤疗效显著

       美国临床肿瘤学会(ASCO)年会公布的两项III期临床研究显示,与化疗相比,trametinib和dabrafenib这两种通过干扰BRAF通路信号发挥作用的新型口服靶向药物,分别使携带BRAF突变的晚期黑色素瘤患者的进展或死亡风险降低55%和70%。此外,这些药物的安全性也较好。因此,trametinib和dabrafenib有望与vemur

Mol Cancer Res:GSK-3或成黑色素瘤治疗新靶点

糖原合成酶激酶-3(glycogen synthase kinase-3,GSK-3)是一种多功能的丝氨酸/苏氨酸蛋白激酶,是细胞内多种信号转导通路中的重要成分,不仅参与细胞内糖代谢过程而且还参与细胞增殖、细胞分化和细胞凋亡等多种重要生理过程。 GSK-3活性受多种机制调节,其活性调节异常时可引起多种重大疾病如糖尿病、神经退行性疾病和肿瘤等。GSK-3已成为许多疾病治疗靶点,目前针对GSK-3靶

Nature:癌症逃避药物治疗之谜

       癌症最可怕的特点之一就是在治疗后能够复发。对于许多类型的癌症,包括称之为黑色素瘤的皮肤癌,个体化药物能够在实验室中根除癌细胞,然而在患者体内却只生成局部的暂时的反应。长期以来癌症研究领域急待解析的一个问题就是:癌症是如何逃避药物治疗的?        来自博德研究所、达纳法伯癌症研究所和麻省总医院的

Cancer Cell:LKB1基因失活驱动黑色素瘤转移

为什么某些癌症会迅速蔓延到其他器官,而某些人却不发生转移?Norman Sharpless博士,领导的UNC研究团队近日确定了一个关键基因开关,该基因决定了一种致命的皮肤癌--黑色素瘤是否会发生转移扩散。 黑色素瘤(melanoma)又称恶性黑色素瘤,是一种能产生黑色素的高度恶性肿瘤。大多见于30岁以上成年人,发生于皮肤、粘膜和内脏器官。黑色素瘤的预后多数较差,晚期可有淋巴道及血液转移。黑色素瘤

NICE拒绝推荐威罗菲尼治疗黑色素瘤

       英国国立健康和临床优化研究所(Nice)决定不推荐威罗菲尼(Zelboraf)作为黑色素瘤患者的治疗选择,理由是该药价格太过昂贵,这一决定已受到皮肤癌患者支持小组的批评。 威罗菲尼(Zelboraf)        Factor 50公司敦促Nice重新考虑其不推荐该药物的决定,因为此药可能是一个

Br J Cancer:miRNA差异表达可能用于黑色素瘤的诊断或预后指标

恶性黑色素瘤的发病率正在逐年上升,并且其上升速度比任何其他癌症都要快。皮肤切除活检仍然是黑色素瘤诊断和预后判断的标准方法。良性和恶性病变组织之间有显著的形态重叠,肿瘤的厚度并不总是一个准确的预测指标。 因此确定新的分子标记物以支持组织学检查非常有必要,近日研究人员对不同病理阶段的福尔马林固定、石蜡包埋的样本进行微陈列分析,以便识别差异表达的微小RNA(miRNA)。相关研究论文发表在Britis

Baidu
map
Baidu
map
Baidu
map