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JAMA:保护好你的心血管!能使痴呆风险降低10%!

2018-09-04 MedSci MedSci原创

近日,法国波尔多大学的研究人员有了一项有趣的发现,保护心血管系统也许会有意外收获,大脑可以坐收渔翁之利!也就是说,要想保护大脑,先得保护好我们的心脏! 我们知道,合理饮食,运动和控制胆固醇是减少心脏病风险的有效措施。但是,你们知道吗?心血管问题很有可能会“迁怒”于大脑。狭窄,阻塞或渗漏的血管可导致中风,而中风恰恰是痴呆的第二大病因。 近日,法国波尔多大学开展了一项新的观察性研究,研究基

近日,法国波尔多大学的研究人员有了一项有趣的发现,保护血管系统也许会有意外收获,大脑可以坐收渔翁之利!也就是说,要想保护大脑,先得保护好我们的心脏!

我们知道,合理饮食,运动和控制胆固醇是减少心脏病风险的有效措施。但是,你们知道吗?血管问题很有可能会“迁怒”于大脑。狭窄,阻塞或渗漏的血管可导致中风,而中风恰恰是痴呆的第二大病因。

近日,法国波尔多大学开展了一项新的观察性研究,研究基于美国心脏协会(AHA)的七项心血管健康指标,结果表明:七项心血管健康指标的评分越高,在随后几年中患痴呆症的风险就越低。对于处于最佳水平的每个指标,痴呆症的风险下降约10%。

该研究于近日以“Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia ”为题发表在著名学术期刊JAMA上。

详解七项心血管健康指标

行为指标:

1、饮食

2、运动

3、体重管理

4、吸烟状况

生物学指标:

1、血压

2、血糖

3、胆固醇

研究对象为6,626名老年人,平均随访8.5年。在此期间,共有745人被诊断患有痴呆症。结果显示:

在得分最低的人群中,痴呆症的发病率为每100人13.3例。但在得分最高的人群中,每100人中只有7.1例。

研究人员于1999年招募了法国波尔多,第戎和蒙彼利埃的居民。所有参与者均无痴呆症或心血管疾病史,在参加研究时至少65岁(平均年龄为73.7岁),他们接受了一系列身体和认知测试和痴呆筛查

研究人员根据他们与七种心血管健康指标中每一种的“最佳水平”相匹配的程度来评估每个人。

 研究参与者的每个类别得分为0,1或2,以反映他们对AHA目标的依从性是“差”,“中度”还是“最佳”。

他们将这些措施的最佳水平定义为:

从未吸烟或戒烟至少12个月

定期进行体育锻炼,例如每周至少走8小时或每周走4小时或更多中等强度的运动或休闲活动

每天至少一份生蔬菜,新鲜水果,熟水果或蔬菜,每周两份或更多份鱼

体重指数(BMI)低于25

总胆固醇低于200毫克/分升,未服药物

血压低于120/80毫米汞柱,未服药物

空腹血糖低于100毫克/分升,未经治疗

结果表明:

36.5%的人在0-2的测量中处于最佳水平

57.1%在3-4个测量中达到最佳水平

仅有6.5%的人达到5-7个。

研究者解释说:假想一下,一名73岁的男性受教育程度低,且没有携带与阿尔茨海默病风险增加有关的基因。如果这名男子不符合任何AHA标准,那么他的认知水平将需要大约六年时间才会下降一个“标准单位”。但是,如果他满足所有七个AHA标准,那么他的认知水平下降相同数量需要两倍的时间。

当然,人们从不良状态演变为最佳状态绝非一朝一夕所能完成。但是良好的心血管健康与更少的大脑白质损害的迹象联系在一起。这无疑可以激励人们达到“中等”状态,促进心血管健康,以预防与认知能力下降和痴呆相关的风险因素。

但是该研究也有其固有的局限性,那就是没有追踪心血管健康随时间的变化,因此无法知道改善一个人的心血管健康是否与较低的痴呆风险相关。研究对象主要是生活在城市环境中的白人,也并不具有典型性。

总之,事实证明,心脏与大脑早已是同气连枝。所以,为了大脑的健康,还是养成良好的生活习惯,保护好心脏吧!

参考文献:

Samieri C, Perier MC, Gaye B, Proust-Lima C, Helmer C, Dartigues JF, Berr C, Tzourio C, Empana JP. Association of Cardiovascular Health Level in Older Age With Cognitive Decline and IncidentDementia. JAMA. 2018 Aug 21;320(7):657-664. 

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    2018-09-06 liumin1987

    谢谢分享,学习了。

    0

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    2018-09-05 smartxiuxiu

    健康生活方式多重要

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1820674, encodeId=bdc018206e411, content=<a href='/topic/show?id=0c6a1009105e' target=_blank style='color:#2F92EE;'>#风险降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100910, encryptionId=0c6a1009105e, topicName=风险降低)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Thu May 02 21:39:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316713, encodeId=3f361316e13f0, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Thu Sep 06 13:39:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343211, encodeId=be71343211c1, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Thu Sep 06 06:38:51 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342873, encodeId=cb763428e34a, content=健康生活方式多重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Wed Sep 05 08:48:39 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342862, encodeId=c09334286205, content=减肥预示着好的预后,运动起来吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Wed Sep 05 06:48:01 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048494, encodeId=2936104849459, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Sep 05 01:39:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342802, encodeId=b8de342802c4, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Sep 04 23:23:13 CST 2018, time=2018-09-04, status=1, ipAttribution=)]
    2018-09-05 太阳系小猪

    减肥预示着好的预后,运动起来吧!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1820674, encodeId=bdc018206e411, content=<a href='/topic/show?id=0c6a1009105e' target=_blank style='color:#2F92EE;'>#风险降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100910, encryptionId=0c6a1009105e, topicName=风险降低)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Thu May 02 21:39:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316713, encodeId=3f361316e13f0, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Thu Sep 06 13:39:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343211, encodeId=be71343211c1, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Thu Sep 06 06:38:51 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342873, encodeId=cb763428e34a, content=健康生活方式多重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Wed Sep 05 08:48:39 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342862, encodeId=c09334286205, content=减肥预示着好的预后,运动起来吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Wed Sep 05 06:48:01 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048494, encodeId=2936104849459, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Sep 05 01:39:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342802, encodeId=b8de342802c4, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Sep 04 23:23:13 CST 2018, time=2018-09-04, status=1, ipAttribution=)]
    2018-09-05 junJUN

    老年人痴呆何药可用??

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1820674, encodeId=bdc018206e411, content=<a href='/topic/show?id=0c6a1009105e' target=_blank style='color:#2F92EE;'>#风险降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100910, encryptionId=0c6a1009105e, topicName=风险降低)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Thu May 02 21:39:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316713, encodeId=3f361316e13f0, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Thu Sep 06 13:39:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343211, encodeId=be71343211c1, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Thu Sep 06 06:38:51 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342873, encodeId=cb763428e34a, content=健康生活方式多重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Wed Sep 05 08:48:39 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342862, encodeId=c09334286205, content=减肥预示着好的预后,运动起来吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Wed Sep 05 06:48:01 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048494, encodeId=2936104849459, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Wed Sep 05 01:39:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342802, encodeId=b8de342802c4, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Sep 04 23:23:13 CST 2018, time=2018-09-04, status=1, ipAttribution=)]
    2018-09-04 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

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