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J Clin Invest:盐摄入与体内液体平衡的调节

2017-04-18 MedSci MedSci原创

增加盐份的摄入量可以增加饮水和尿量的说法已被广泛接受。近期,一项发表在杂志J Clin Invest上的研究评估了男性生活在超长期受控条件下,若盐的摄入量增加至6 g / d会是否会改变体内液体的平衡。在持续时间105天和205天的2次单独的太空飞行模拟研究过程中,研究者们予以10名健康男子3种盐摄入量(12,9或6g / d)。其他所有营养物质都保持不变。其后研究了盐驱动的盐皮质激素和糖皮质激素

增加盐份的摄入量可以增加饮水和尿量的说法已被广泛接受。近期,一项发表在杂志J Clin Invest上的研究评估了男性生活在超长期受控条件下,若盐的摄入量增加至6 g / d会是否会改变体内液体的平衡。


在持续时间105天和205天的2次单独的太空飞行模拟研究过程中,研究者们予以10名健康男子3种盐摄入量(12,9或6g / d)。其他所有营养物质都保持不变。其后研究了盐驱动的盐皮质激素和糖皮质激素尿排泄对渗透液和水平衡的影响。

此项研究结果显示:盐摄入量增加至6 g / d可增加尿液渗透液的排泄,但自由水清除率降低,表明尿液浓度可以增加内源性游离水。而在12g / d盐摄入水平下,所产生的内源性水分过剩减少了液体摄入量。

在所有3个盐摄入水平,半周和每周有节律的盐皮质激素释放通过肾脏浓度机制促进游离水的重吸收。游离水重吸收的皮质激素耦合的增加被节律性糖皮质激素的释放抵消,这一过程通过相对尿稀释排泄内源性渗透液和水分过剩。

盐摄入量增加至6 g/d会降低有节律的盐皮质激素释放,并提高节律性糖皮质激素释放的水平。盐驱动激素节律调节的预期效果与测量的水分摄入量减少以及随着渗透液排泄量的增加而增加。

此项研究表明:人类通过有节律的盐皮质激素和糖皮质激素释放,内源性增加身体剩余的水份以及精确排泄多余水分的方式来调节渗透液和水平衡。

原始出处:
Rakova N, Kitada K, et al. Increased salt consumption induces body water conservation and decreases fluid intake. J Clin Invest. 2017 Apr 17. pii: 88530. doi: 10.1172/JCI88530.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1988908, encodeId=87a2198890855, content=<a href='/topic/show?id=737ce226189' target=_blank style='color:#2F92EE;'>#盐摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72261, encryptionId=737ce226189, topicName=盐摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Fri Aug 04 04:57:00 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050648, encodeId=46db2050648ec, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Jun 11 21:57:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188573, encodeId=1a3c1885e336, content=不错啊,很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJMGWCeYPA7M6D1SXW1cvica6icvoQw3peyZNDFibUN2LQVpnEs45icKVlyAaPMs2kLElia1F3QDDaHFXQ/0, createdBy=4acf2050790, createdName=许小刀, createdTime=Tue Apr 18 20:12:42 CST 2017, time=2017-04-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1988908, encodeId=87a2198890855, content=<a href='/topic/show?id=737ce226189' target=_blank style='color:#2F92EE;'>#盐摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72261, encryptionId=737ce226189, topicName=盐摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Fri Aug 04 04:57:00 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050648, encodeId=46db2050648ec, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Jun 11 21:57:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188573, encodeId=1a3c1885e336, content=不错啊,很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJMGWCeYPA7M6D1SXW1cvica6icvoQw3peyZNDFibUN2LQVpnEs45icKVlyAaPMs2kLElia1F3QDDaHFXQ/0, createdBy=4acf2050790, createdName=许小刀, createdTime=Tue Apr 18 20:12:42 CST 2017, time=2017-04-18, status=1, ipAttribution=)]
    2017-04-18 许小刀

    不错啊,很有用

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