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Stroke: 青年缺血性卒中患者,急性期血压升高与卒中复发相关

2016-06-01 MedSci MedSci原创

背景:急性脑卒中患者血压(BP)升高与预后不良有关,但尚未在年轻人中进行研究。方法:在赫尔辛基青年卒中记录中招募15岁到49岁首发缺血性卒中的患者,评估1004例患者BP和长期预后的相关性。BP参数入院和24h时收缩压(SBP)和舒张压、脉压和平均动脉压。主要预后指标为在长期的随访中卒中复发。校正人口学和已经存在的合并症,采用Cox回归模型评估BP参数和预后的相关性。结果:在研究的患者中(男63%

背景:急性脑卒中患者血压(BP)升高与预后不良有关,但尚未在年轻人中进行研究。

方法:在赫尔辛基青年卒中记录中招募15岁到49岁首发缺血性卒中的患者,评估1004例患者BP和长期预后的相关性。BP参数入院和24h时收缩压(SBP)和舒张压、脉压和平均动脉压。主要预后指标为在长期的随访中卒中复发。校正人口学和已经存在的合并症,采用Cox回归模型评估BP参数和预后的相关性。

结果:在研究的患者中(男63%例),393例(39%)在卒中前有高血压,358例(36%)使用抗高血压药物治疗。随访的中位数为8.9年(四分位距:5.7-13.2)。与卒中未复发的患者相比,卒中复发的患者(n = 142,14%),入院时收缩压、舒张压、脉压、平均动脉压和24h收缩压、舒张压和平均动脉压均较高。在随访期间,收缩压≥160毫米汞柱比收缩压<160 mm Hg的患者卒中复发率较高(HR 3.3 [ 95%CI,2.05-4.55 ]),并且卒中复发更早(13.9年13.0-14.6 ] vs 16.2年 [ 15.8-16.6 ])。在多变量分析中,高入院收缩压、舒张压、脉压、平均动脉压与脑卒中复发的风险独立相关,24小时血压水平与卒中复发不相关。

结论:在青年缺血性脑卒中患者中,急性期血压水平升高与卒中复发的高风险相关。

原始出处:

Mustanoja S, Putaala J, et al. Acute-Phase Blood Pressure Levels Correlate With a High Risk of Recurrent Strokes in Young-Onset Ischemic Stroke. Stroke. 2016 Jun;

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    2016-10-13 ylzr123

    学习了,好文值得点赞!

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1806087, encodeId=a23e180608e6d, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Dec 31 05:19:00 CST 2016, time=2016-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720114, encodeId=20471e201148c, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Tue Oct 18 02:19:00 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718931, encodeId=16041e189313b, content=<a href='/topic/show?id=32b888935ca' target=_blank style='color:#2F92EE;'>#血压升高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88935, encryptionId=32b888935ca, topicName=血压升高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c86e32676392, createdName=zhang92571, createdTime=Mon Nov 14 03:19:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=147519, encodeId=000214e519c4, content=学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Oct 13 10:37:57 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892758, encodeId=72d61892e5849, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Jun 08 07:19:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010350, encodeId=eb22201035022, content=<a href='/topic/show?id=9cf7e9360d2' target=_blank style='color:#2F92EE;'>#缺血性卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79360, encryptionId=9cf7e9360d2, topicName=缺血性卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Sat Sep 10 13:19:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1678257, encodeId=5e5216e8257c0, content=<a href='/topic/show?id=12025231333' target=_blank style='color:#2F92EE;'>#急性期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52313, encryptionId=12025231333, topicName=急性期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b8027680692, createdName=feifers, createdTime=Wed Oct 19 02:19:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391599, encodeId=493713915997c, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Fri Jun 03 07:19:00 CST 2016, time=2016-06-03, status=1, ipAttribution=)]
    2016-10-19 feifers
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