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J Endod：分子靶向环状di-AMP合成酶的活性会抑制粪肠球菌生长和生物膜形成

2018-08-09 lishiting MedSci原创

DisA粪肠球菌
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粪肠球菌因其生物膜形成的能力以及不同的毒力因子作用，常与根管治疗反复失败等口腔疾病相关联。Cyclic di-AMP (c-di-AMP)是一个遍在第二信使，存在于多种重要的细胞生理过程，包括生物膜形成。ST056083为小分子物质，它是体外c-di-AMP合成酶DNA完整性扫描蛋白(DisA)的抑制剂。这篇研究的目的是为了评估ST056083对粪肠球菌DisA活性、菌斑生长和生物膜形成的影响。

粪肠球菌因其生物膜形成的能力以及不同的毒力因子作用，常与根管治疗反复失败等口腔疾病相关联。Cyclic di-AMP (c-di-AMP)是一个遍在第二信使，存在于多种重要的细胞生理过程，包括生物膜形成。ST056083为小分子物质，它是体外c-di-AMP合成酶DNA完整性扫描蛋白(DisA)的抑制剂。这篇研究的目的是为了评估ST056083对粪肠球菌DisA活性、菌斑生长和生物膜形成的影响。研究采用Amber评分评估蛋白和配体的亲和力，采用UCSF Chimera (Resource for Biocomputing， Visualization， and Informatics， University of California， San Francisco， San Francisco， CA)分析和观察其结合方式。采用coralyne分析评估ST056083对粪肠球菌DisA活性的影响。采用生物膜定量分析、扫描电子显微镜和3D激光共聚焦扫描电镜测定评估ST056083对粪肠球菌菌斑生物膜形成的影响。采用anthrone-sulfuric法检测ST056083对粪肠球菌表多糖合

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1986938, encodeId=a9f5198693856, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Mon Jun 17 22:39:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491724, encodeId=7c3a1491e24c5, content=<a href='/topic/show?id=130a8158305' target=_blank style='color:#2F92EE;'>#肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81583, encryptionId=130a8158305, topicName=肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3c98898784, createdName=psybestwish, createdTime=Sat Aug 11 13:39:00 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531241, encodeId=7704153124191, content=<a href='/topic/show?id=3b5ee633753' target=_blank style='color:#2F92EE;'>#粪肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76337, encryptionId=3b5ee633753, topicName=粪肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f72712226339, createdName=hb2012ye, createdTime=Sat Aug 11 13:39:00 CST 2018, time=2018-08-11, status=1, ipAttribution=)]
    2019-06-17 yyanpro@21cn.c

    #分子靶向#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1986938, encodeId=a9f5198693856, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Mon Jun 17 22:39:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491724, encodeId=7c3a1491e24c5, content=<a href='/topic/show?id=130a8158305' target=_blank style='color:#2F92EE;'>#肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81583, encryptionId=130a8158305, topicName=肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3c98898784, createdName=psybestwish, createdTime=Sat Aug 11 13:39:00 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531241, encodeId=7704153124191, content=<a href='/topic/show?id=3b5ee633753' target=_blank style='color:#2F92EE;'>#粪肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76337, encryptionId=3b5ee633753, topicName=粪肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f72712226339, createdName=hb2012ye, createdTime=Sat Aug 11 13:39:00 CST 2018, time=2018-08-11, status=1, ipAttribution=)]
    2018-08-11 psybestwish

    #肠球菌#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1986938, encodeId=a9f5198693856, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Mon Jun 17 22:39:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491724, encodeId=7c3a1491e24c5, content=<a href='/topic/show?id=130a8158305' target=_blank style='color:#2F92EE;'>#肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81583, encryptionId=130a8158305, topicName=肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3c98898784, createdName=psybestwish, createdTime=Sat Aug 11 13:39:00 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531241, encodeId=7704153124191, content=<a href='/topic/show?id=3b5ee633753' target=_blank style='color:#2F92EE;'>#粪肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76337, encryptionId=3b5ee633753, topicName=粪肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f72712226339, createdName=hb2012ye, createdTime=Sat Aug 11 13:39:00 CST 2018, time=2018-08-11, status=1, ipAttribution=)]
    2018-08-11 hb2012ye

    #粪肠球菌#

    0

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