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JCEM:1岁幼儿体内的成纤维细胞生长因子23(FGF23)浓度受哪些因素调控?

2017-10-31 MedSci MedSci原创

背景:磷是人体内最丰富的元素之一,体内磷的多以磷酸盐(PO4)形式存在。成人正常血浆PO4浓度介于2.5~4.5mg/dl(0.81-1.45mmol/L),婴儿PO4要高50%,儿童高30%,大概是因为生长需要较高的磷酸盐。成纤维细胞生长因子23(FGF23)在磷酸盐代谢中起着重要的作用,但目前的研究不能充分解释它的调节特征。目的:本研究探讨了在儿童早期时FGF23受哪些因素调控,特别是性别和铁

背景:磷是人体内最丰富的元素之一,体内磷的多以磷酸盐(PO4)形式存在。成人正常血浆PO4浓度介于2.5~4.5mg/dl(0.81-1.45mmol/L),婴儿PO4要高50%,儿童高30%,大概是因为生长需要较高的磷酸盐。成纤维细胞生长因子23(FGF23)在磷酸盐代谢中起着重要的作用,但目前的研究不能充分解释它的调节特征。目的:本研究探讨了在儿童早期时FGF23受哪些因素调控,特别是性别和铁状态。方法:这是一项横断面研究,研究涉及1岁的幼儿。来自芬兰赫尔辛--Katiloopisto妇产科医院的研究人员招募了出生体重适于胎龄的健康足月儿,对他们进行了维生素D测试。在幼儿12个月时,研究人员随访了他们的血清FGF23、25羟维生素D(25OHD)、磷酸钙、甲状旁腺激素(PTH)和铁营养状况。研究纳入了所有721名幼儿(51%为女孩)的完整数据。主要观察指标:幼儿1岁时的成熟全段和C段FGF23浓度和铁状态。结果:女孩比男孩的全段FGF23浓度要高,中位数(IQR)分别为44.4(36.8,51.9)pg/ml和40.9(34.5,49)pg/ml(P<0.001)。男孩和女孩的C段

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  1. 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    2018-09-27 achengzhao
  2. 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  3. 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  4. 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topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258005, encodeId=09fb25800570, content=内容很好.收藏了.以后用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=214, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Nov 02 08:12:28 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
  5. 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topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258005, encodeId=09fb25800570, content=内容很好.收藏了.以后用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=214, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Nov 02 08:12:28 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
  6. 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  7. 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createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544477, encodeId=972715444e766, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569011, encodeId=e23f1569011fa, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258005, encodeId=09fb25800570, content=内容很好.收藏了.以后用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=214, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Nov 02 08:12:28 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
    2017-11-02 虈亣靌

    内容很好.收藏了.以后用的到

    0

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