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JAMA Neurol:安慰剂对神经痛症状的影响

2018-08-01 zhangfan MedSci原创

研究认为,安慰剂效应对疼痛报告评估具有中等程度的缓解作用,对伤害性疼痛的缓解作用微乎其微

安慰剂效应可减轻疼痛并有助于临床镇痛,但安慰剂效益的真正因素尚不清楚。近日研究人员开展系统综述及荟萃分析考察了安慰剂效应对神经痛征(NPS)中的疼痛相关功能神经反应的影响。

研究人员收集并整合了2015年5月前的相关文献资料,涉及安慰剂和对照治疗后,疼痛相关人脑功能神经响应的研究纳入本次荟萃分析。研究的主要终点为NPS响应,次要终点为疼痛报告。

20个研究,总计603名志愿者资料纳入本次荟萃研究中。研究发现,575名参与者(95.4%)对疼痛刺激做出NPS响应,表现为伤害性疼痛敏感性。85%的研究证实安慰剂效应对疼痛评分的行为结果有显著影响,但仅15%的研究证实安慰剂效应对NPS响应有影响。

研究认为,安慰剂效应对疼痛报告评估具有中等程度的缓解作用,对伤害性疼痛的缓解作用微乎其微。

原始出处:


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    2019-03-20 yinhl1978
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    2018-08-03 smartxiuxiu

    有点意思,成瘾者真的会用安慰剂

    0

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    2018-08-02 贵阳
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    2018-08-01 lixon1988

    安慰剂效应对疼痛报告评估具有中等程度的缓解作用,对伤害性疼痛的缓解作用微乎其微。

    0

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    2018-08-01 flysky120

    安慰剂希望能有好作用

    0

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    2018-08-01 1ddf0692m34(暂无匿称)

    学习了,长知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2000522, encodeId=b1cc200052232, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Mar 20 03:50:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336060, encodeId=598e33606023, content=有点意思,成瘾者真的会用安慰剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Aug 03 17:41:54 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304357, encodeId=6651130435e2c, content=<a href='/topic/show?id=81724580886' target=_blank style='color:#2F92EE;'>#安慰剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45808, encryptionId=81724580886, topicName=安慰剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Thu Aug 02 21:50:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540819, encodeId=29481540819ff, content=<a href='/topic/show?id=ac8de440615' target=_blank style='color:#2F92EE;'>#神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74406, encryptionId=ac8de440615, topicName=神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d8213287489, createdName=贵阳, createdTime=Thu Aug 02 21:50:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335575, encodeId=87603355e59a, content=安慰剂效应对疼痛报告评估具有中等程度的缓解作用,对伤害性疼痛的缓解作用微乎其微。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRtpPKU0wCQJX0qlicBd0iaQKZSwfxZJgU3Ep22UHmz5TRb7GYJePEmLTeibImwstiaEU5lqUQNCicibGkn/0, createdBy=bdcb1652180, createdName=lixon1988, createdTime=Wed Aug 01 17:38:17 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335491, encodeId=50a833549137, content=安慰剂希望能有好作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Aug 01 09:06:14 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335482, encodeId=cbf3335482f8, content=学习了,长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Aug 01 08:29:14 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335477, encodeId=98f83354e743, content=优质资源,共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Wed Aug 01 07:47:16 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335452, encodeId=e00733545299, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Wed Aug 01 07:00:31 CST 2018, time=2018-08-01, status=1, ipAttribution=)]
    2018-08-01 九九消寒

    优质资源,共同学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2000522, encodeId=b1cc200052232, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Mar 20 03:50:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336060, encodeId=598e33606023, content=有点意思,成瘾者真的会用安慰剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Aug 03 17:41:54 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304357, encodeId=6651130435e2c, content=<a href='/topic/show?id=81724580886' target=_blank style='color:#2F92EE;'>#安慰剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45808, encryptionId=81724580886, topicName=安慰剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Thu Aug 02 21:50:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540819, encodeId=29481540819ff, content=<a href='/topic/show?id=ac8de440615' target=_blank style='color:#2F92EE;'>#神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74406, encryptionId=ac8de440615, topicName=神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d8213287489, createdName=贵阳, createdTime=Thu Aug 02 21:50:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335575, encodeId=87603355e59a, content=安慰剂效应对疼痛报告评估具有中等程度的缓解作用,对伤害性疼痛的缓解作用微乎其微。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRtpPKU0wCQJX0qlicBd0iaQKZSwfxZJgU3Ep22UHmz5TRb7GYJePEmLTeibImwstiaEU5lqUQNCicibGkn/0, createdBy=bdcb1652180, createdName=lixon1988, createdTime=Wed Aug 01 17:38:17 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335491, encodeId=50a833549137, content=安慰剂希望能有好作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Aug 01 09:06:14 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335482, encodeId=cbf3335482f8, content=学习了,长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Aug 01 08:29:14 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335477, encodeId=98f83354e743, content=优质资源,共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Wed Aug 01 07:47:16 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335452, encodeId=e00733545299, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Wed Aug 01 07:00:31 CST 2018, time=2018-08-01, status=1, ipAttribution=)]
    2018-08-01 zdvfsadb

    学习了

    0

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