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Immunity:肠胃流感快闪!pick诺如病毒疫苗,我国更快一步

2019-06-24 纪大乙 生物探索

诺如病毒引起的感染性腹泻在全世界范围内均有流行,全年流行,感染以轻症为主,主要症状为呕吐、腹泻并伴有胃痛。儿童、老年人以及其它疾病患者症状更为严重,一日内多次呕吐,甚至导致脱水。

诺如病毒引起的感染性腹泻在全世界范围内均有流行,全年流行,感染以轻症为主,主要症状为呕吐、腹泻并伴有痛。儿童、老年人以及其它疾病患者症状更为严重,一日内多次呕吐,甚至导致脱水。

诺如病毒已知基因型有30多种,但是人类诺如病毒60%的爆发是由GII.4基因型引起的。人类诺如病毒通过与肠道粘膜表面上的组织间抗原(HBGAs;通常为A,B,O或Lewis抗原)结合而附着于细胞表面。美国疾病控制和预防中心(CDC)指出,诺如病毒感染者可以排出数十亿个诺如病毒颗粒,只有少数病毒颗粒可使其他人患病。然而迄今为止并没有针对诺如病毒的特异性抗体,因为诺如病毒变异速度太快了!

北卡罗来纳大学(UNC)Chapel Hill Gillings全球公共卫生学院的研究人员发现了一种可以广泛抑制多型诺如病毒的抗体,在应对可怕的肠流感上迈出了重要的一步。

“为了设计一种有效的诺如病毒疫苗,科学家们需要确定一种中和抗体。这种抗体能应对多种菌株,以及将来传播的菌株,”UNC流行病学教授、该研究的主要作者Baric说,“这些信息可以用来制造更好的人用疫苗。”

研究小组首先建立了免疫接种前后存在的GII.4抗体库,并选择了几个进行表位和结构分析。研究人员发现,接种疫苗后的抗体被以前的诺如病毒感染极化并形成,“GII.4特异性抗体阻断祖先菌株或结合不同基因型的抗体,并且不阻断病毒进入配体相互作用。”之后研究人员对抗体识别位点进行确认。

A1431是一种广泛的阻断性中和抗体,其结合位点在结构上已经被确定。该研究发现抗体A1431对GII.4菌株表现出广泛的阻断,并能中和各类GII.4流行菌株。A1431能识别HBGAs结合区远端但可在组装的病毒颗粒上访问的保守残基。晶体结构分析发现具有衣壳蛋白P结构域的A1431潜在地提供了通过其可以进一步改善该抗体的广泛性和效力的途径。

这项工作首次描述了诺如病毒和人类抗体之间的结合相互作用的结构,并证明感染衍生的和疫苗诱发的抗体可以表现出针对这种普遍的人类病原体的广泛阻断和中和。

作者指出,“这些抗体类别中的每一种都可能有助于疫苗诱导的保护,需要进一步的研究和体内模型来充分了解抗体靶标与生理反应之间的相互作用。”

除此之外,我国在诺如病毒疫苗上也传来捷报。我国科学家自主研发、国际首个诺如病毒四价疫苗正式获批进入临床研究。

该疫苗包含四种诺如病毒主要流行基因型的重组病毒样颗粒抗原,理论上可以预防80%至90%的诺如病毒感染及其引起的急性胃肠炎,是目前全球范围内,获得临床许可价次最高的多价诺如病毒疫苗。

我们期待这款疫苗完成临床研究,实现上市,克服诺如!

参考文献:

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    2019-07-02 14607dd8m74暂无昵称

    学习了,谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-07-01 14607dd8m74暂无昵称

    学习了,谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-06-30 14607dd8m74暂无昵称

    学习了,谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-06-29 14607dd8m74暂无昵称

    很好的学习资料,谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-06-28 14607dd8m74暂无昵称

    学习了,谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-06-27 14607dd8m74暂无昵称

    学习了,很好的学习资料

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
  10. [GetPortalCommentsPageByObjectIdResponse(id=2030394, encodeId=9f562030394fa, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Feb 15 14:45:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083306, encodeId=582220833065c, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Dec 09 23:45:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368819, encodeId=b49736881913, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jul 02 09:25:25 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368746, encodeId=b6a4368e4681, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Mon Jul 01 08:20:37 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368650, encodeId=692736865027, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sun Jun 30 10:49:47 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368613, encodeId=ccf13686136e, content=很好的学习资料,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Sat Jun 29 17:36:09 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368536, encodeId=616536853649, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Fri Jun 28 12:21:53 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368452, encodeId=b4cb36845265, content=学习了,很好的学习资料, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Thu Jun 27 08:20:29 CST 2019, time=2019-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479210, encodeId=297414e9210a5, content=<a href='/topic/show?id=82d0919287c' target=_blank style='color:#2F92EE;'>#诺如病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91928, encryptionId=82d0919287c, topicName=诺如病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8627501386, createdName=丁鹏鹏, createdTime=Wed Jun 26 07:45:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368324, encodeId=d67a36832409, content=学习了,学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ce65106991, createdName=14607dd8m74暂无昵称, createdTime=Tue Jun 25 13:12:04 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-06-25 14607dd8m74暂无昵称

    学习了,学习分享

    0

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