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2019年美国皮肤病学（AAD）大会：Risankizumab在中重度银屑病中比Ustekinumab更有效

2019-03-11 不详 网络

中重度银屑病risankizumab皮肤病
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根据对III期UltlMMa-1和UltlMMa-2试验的综合分析，对于中度至重度银屑病患者，risankizumab在治疗52周后显示出优于ustekinumab的有效性。

根据对III期UltlMMa-1和UltlMMa-2试验的综合分析，对于中度至重度银屑病患者，risankizumab在治疗52周后显示出优于ustekinumab的有效性。

墨尔本大学圣文森特医院的FACD医学博士Peter Foley于3月2日提交了这项研究。Foley博士及其同事以3：3：1的方式随机分配中度至重度银屑病患者，接受risankizumab 150mg（n = 598），ustekinumab 45或90mg（n = 199）或安慰剂（n = 200）的治疗 。

在研究的A部分（第0-4周），患者在第0、4、16、28和40周接受注射。在第16周，接受安慰剂的患者转换为risankizumab150mg。在B部分（第16-52周），患者在第16周、第28周和第40周接受risankizumab或ustekinumab。结果显示，Risankizumab治疗的患者在PASI90上得分显著较高（银屑病面积和严重程度指数从基线降低≥90％的患者百分比）。静态医师全面评估（sPGA）显示，Risankizumab的功效明显优于ustekinumab治疗的患者（P <0.001）。


原始出处：

http://www.firstwordpharma.com/node/1628635#axzz5houfIuVA

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1826125, encodeId=11bf182612524, content=<a href='/topic/show?id=f6a6e206066' target=_blank style='color:#2F92EE;'>#皮肤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72060, encryptionId=f6a6e206066, topicName=皮肤病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Feb 13 19:57:00 CST 2020, time=2020-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642710, encodeId=182a1642e1075, content=<a href='/topic/show?id=39071820109' target=_blank style='color:#2F92EE;'>#ustekinumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18201, encryptionId=39071820109, topicName=ustekinumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ae023003775, createdName=12498f1em15(暂无昵称), createdTime=Sat Aug 10 02:57:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024478, encodeId=2fe920244e8d2, content=<a href='/topic/show?id=0cf12259156' target=_blank style='color:#2F92EE;'>#中重度银屑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22591, encryptionId=0cf12259156, topicName=中重度银屑病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue May 28 05:57:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912106, encodeId=3f761912106e4, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Aug 21 04:57:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362441, encodeId=c97636244134, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Mar 11 09:11:56 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362440, encodeId=d1f83624409b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Mar 11 09:11:53 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2020-02-13 一叶知秋

    #皮肤病#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1826125, encodeId=11bf182612524, content=<a href='/topic/show?id=f6a6e206066' target=_blank style='color:#2F92EE;'>#皮肤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72060, encryptionId=f6a6e206066, topicName=皮肤病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Feb 13 19:57:00 CST 2020, time=2020-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642710, encodeId=182a1642e1075, content=<a href='/topic/show?id=39071820109' target=_blank style='color:#2F92EE;'>#ustekinumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18201, encryptionId=39071820109, topicName=ustekinumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ae023003775, createdName=12498f1em15(暂无昵称), createdTime=Sat Aug 10 02:57:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024478, encodeId=2fe920244e8d2, content=<a href='/topic/show?id=0cf12259156' target=_blank style='color:#2F92EE;'>#中重度银屑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22591, encryptionId=0cf12259156, topicName=中重度银屑病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue May 28 05:57:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912106, encodeId=3f761912106e4, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Aug 21 04:57:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362441, encodeId=c97636244134, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Mar 11 09:11:56 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362440, encodeId=d1f83624409b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Mar 11 09:11:53 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-08-10 12498f1em15(暂无昵称)

    #ustekinumab#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1826125, encodeId=11bf182612524, content=<a href='/topic/show?id=f6a6e206066' target=_blank style='color:#2F92EE;'>#皮肤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72060, encryptionId=f6a6e206066, topicName=皮肤病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Feb 13 19:57:00 CST 2020, time=2020-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642710, encodeId=182a1642e1075, content=<a href='/topic/show?id=39071820109' target=_blank style='color:#2F92EE;'>#ustekinumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18201, encryptionId=39071820109, topicName=ustekinumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ae023003775, createdName=12498f1em15(暂无昵称), createdTime=Sat Aug 10 02:57:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024478, encodeId=2fe920244e8d2, content=<a href='/topic/show?id=0cf12259156' target=_blank style='color:#2F92EE;'>#中重度银屑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22591, encryptionId=0cf12259156, topicName=中重度银屑病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue May 28 05:57:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912106, encodeId=3f761912106e4, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Aug 21 04:57:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362441, encodeId=c97636244134, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Mar 11 09:11:56 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362440, encodeId=d1f83624409b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Mar 11 09:11:53 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-05-28 zhzhxiang

    #中重度银屑病#

    0

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    2019-08-21 snf701207

    #mAb#

    0

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    2019-03-11 明月清辉

    谢谢分享学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1826125, encodeId=11bf182612524, content=<a href='/topic/show?id=f6a6e206066' target=_blank style='color:#2F92EE;'>#皮肤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72060, encryptionId=f6a6e206066, topicName=皮肤病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Feb 13 19:57:00 CST 2020, time=2020-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642710, encodeId=182a1642e1075, content=<a href='/topic/show?id=39071820109' target=_blank style='color:#2F92EE;'>#ustekinumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18201, encryptionId=39071820109, topicName=ustekinumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ae023003775, createdName=12498f1em15(暂无昵称), createdTime=Sat Aug 10 02:57:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024478, encodeId=2fe920244e8d2, content=<a href='/topic/show?id=0cf12259156' target=_blank style='color:#2F92EE;'>#中重度银屑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22591, encryptionId=0cf12259156, topicName=中重度银屑病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Tue May 28 05:57:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912106, encodeId=3f761912106e4, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Aug 21 04:57:00 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362441, encodeId=c97636244134, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Mar 11 09:11:56 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362440, encodeId=d1f83624409b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Mar 11 09:11:53 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
    2019-03-11 龙胆草

    学习谢谢分享

    0

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