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BMJ:青少年时期体重指数对晚年心血管、糖尿病及肿瘤风险的影响

2020-05-08 MedSci原创 MedSci原创

青少年时期体重指数较高或与较低的乳腺癌风险相关

近日研究人员评估了青少年时期体重指数对晚年患病风险的影响。
 
研究人员收集了英国生物银行和四个大规模全基因组关联研究(GWAS)数据,英国生物银行队列包含453169名参与者,GWAS研究包含超过700000名参与者,测量参与者56.5岁时的体重指数,参与者自我报告10岁时BMI。研究的主要终点为冠状动脉疾病,II型糖尿病,乳腺癌和前列腺癌。
 
单变量孟德尔随机化分析表明,青少年时期较高的BMI与冠状动脉疾病(1.49)和II型糖尿病(2.32)的发病率增加相关。然而,基于多变量孟德尔随机化研究,青少年时期BMI对冠状动脉疾病(1.02)和II型糖尿病(1.16)风险无显著影响,但较高的青少年时期BMI可降低乳腺癌风险(0.59),未发现青少年BMI对前列腺癌风险的影响。
 
研究认为,青少年时期体重指数较高或与较低的乳腺癌风险相关。
 
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    2021-01-17 gaoxiaoe
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    2020-05-09 qingfengqishi5

    学习了,学习了

    0

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    2020-05-08 misszhang

    谢谢MedSci提供最新的资讯

    0

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