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JAMA:轮班制增加心脏病风险,医务人员尤其如此

2016-04-27 MedSci MedSci原创

背景民众对轮班制工作与患冠心病(CHD)风险之间的关系并不了解,且既往研究都仅对参与者进行短期随访,结果并不具备可信性。 目的该研究的目的是评估轮班工作是否增加民众患冠心病的风险。 方式该研究为前瞻性队列研究,共有189158名参与护士1期健康研究(NHS,1988-2012,N=73623)和护士2期健康研究(NHS2,1989-2013,N =115535)的健康女性参与研究,研究人员对她们进

背景
民众对轮班制工作与患冠心病(CHD)风险之间的关系并不了解,且既往研究都仅对参与者进行短期随访,结果并不具备可信性。 


目的
该研究的目的是评估轮班工作是否增加民众患冠心病的风险。 

方式
该研究为前瞻性队列研究,共有189158名参与护士1期健康研究(NHS,1988-2012,N=73623)和护士2期健康研究(NHS2,1989-2013,N =115535)的健康女性参与研究,研究人员对她们进行了长达24年的随访,并收集她们轮值夜班工作(夜班次数≥3次/月)的频率,并每2到4年更新一次。此外,研究人员着重关注参与者出现非致死性心肌梗死、因冠心病死亡、心绞痛、行冠状动脉搭桥手术和血管成形术等CHD事件的民众人数。 

结果
在随访期间,NHS研究中共有7303名参与者(研究开始时参与者平均年龄为54.5岁)出现CHD事件,NHS2研究中共有3519名参与者(平均年龄为34.8岁)出现CHD事件。通过使用多元变量校正的Cox回归模型,研究人员发现,无论在NHS还是NHS2研究中,参与者轮夜班次数越多,今后患CHD的风险越大。在NHS研究中,若参与者轮夜班工作不到5年,则年龄标准化发病率(IR)为435.1/100000病人年(风险比[HR]:1.02,95%CI:0.97-1.08);5-9年轮值夜班工作的参与者IR为525.7/100000病人年(HR:1.12,95%CI:1.12-1.02);轮值夜班10年以上从参与者IR为596.9/100000病人年(HR:1.18,95%CI:1.10-1.26;P<0.001 )。从不轮值夜班工作的参与者IR为425.5/100000病人年。在NHS2研究中,若参与者轮夜班工作不到5年,则IR为130.6(HR:1.05,95%CI:0.97-1.13);5-9年轮值夜班工作的参与者IR为151.6/100000病人年(HR:1.12,95%CI: 0.99-1.26);轮值夜班10年以上从参与者IR为178.0/100000病人年(HR:1.15;95%CI:1.01-1.32,P =0.01);从不轮值夜班的参与者IR为122.6/100000病人年。研究人员发现,NHS研究随访前半段随访时长(<5 年,IR:382.4,HR:1.10,95% CI:1.01-1.21;5-9年,IR:483.1, HR:1.19,95% CI:1.03-1.39;≥10年,IR:494.4,HR:1.27,95%CI:1.13-1.42;P<0.001 )和后半段随访过程(<5年,IR:424.8,HR:0.98,95%CI:0.92-1.05;5-9年IR:520.7, HR:1.08,95% CI:0.96-1.21;≥10年IR:556.2,HR:1.13,95% CI:1.04-1.24)相比,前半段时间内参与者轮值夜班时间与患CHD风险之间的关系更密切。减少轮值夜班工作可降低民众患CHD风险。 

结论
参与女性均为在职护士,因为护士职业群体要密切关注自身的健康状况,因为她们是不可避免轮值夜班,因此会增加患冠心病的风险,但研究人员表示仍需进行更进一步的研究。

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    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

    0

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    2016-08-29 ylzr123

    深入学习,好文值得点赞!

    0

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    2016-07-10 oo902

    提高待遇增加人员是唯一的出路

    0

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    2016-05-09 QQ6709219e

    轮班,任务重,压力大,减负真的很重要

    0

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    2016-05-01 lshanp

    该研究确实是个好思路,只有好的研究思路+重要的临床价值才能发在更好的杂志上,点赞

    0

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    2016-04-28 明崖

    多增加人员轮班才能减轻负担

    0

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