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Nanomaterials：ZnO纳米棒可实现疫苗安全无痛给药

2017-08-11 MedSci MedSci原创

ZnO纳米棒疫苗
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因为皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法。目前研究人员已开发许多皮内注射技术以提高皮肤穿透。然而，这些方法都是侵入性的和/或影响皮肤完整性。因此，本研究设计了氧化锌(ZnO)纳米棒以用于非侵入性药物递送。采用化学气相沉积法在ZnO预涂硅片上制备定向纳米棒。纳米杆的长度和直径取决于溅射硅芯片的温度、时间、质量等。选择长度为30-35µm、直径

因为皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法。目前研究人员已开发许多皮内注射技术以提高皮肤穿透。然而，这些方法都是侵入性的和/或影响皮肤完整性。因此，本研究设计了氧化锌(ZnO)纳米棒以用于非侵入性药物递送。

采用化学气相沉积法在ZnO预涂硅片上制备定向纳米棒。纳米杆的长度和直径取决于溅射硅芯片的温度、时间、质量等。选择长度为30-35µm、直径为200-300 nm的垂直排列的ZnO纳米杆进行体外皮肤渗透研究，使用吸附在纳米杆上的FITC标记的弗兰兹细胞进行研究。

结果，皮肤样品的荧光和共聚焦研究显示，异硫氰酸FITC沿着纳米棒所形成的通道进入皮肤。对收集的流体样品进行Bradford蛋白测定，第一个12小时内，表明有大量异硫氰酸-FITC标记的白蛋白。使用卵清蛋白（OVA）抗原涂覆纳米片免疫Bable/c小鼠可观察到低抗体滴度。尽管如此，由于纳米棒的尺寸减小，本实验的设备提供了额外的优势，同时排除了微生物病原体的进入。

总之，这些结果表明，ZnO纳米棒具有安全、无创及无痛皮内给药的潜力。

原始出处：

Tapas R. Nayak, Hao Wang, et al., ZnO Nano-Rod Devices for Intradermal Delivery and Immunization. Nanomaterials (Basel) 2017 Jun; 7(6): 147. Published online 2017 Jun 15. doi: 10.3390/nano7060147.

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    2017-08-12 lyh994

    皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=232790, encodeId=c5b6232e906b, content=皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Aug 12 09:33:07 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232726, encodeId=dfc5232e260b, content=路过。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEjPHcBWkEawnOHuvuXw3Lxjnzko8jRkakGyVZ27zRcmYACibkCom9Da1icAJBDFrbJelRNtMRic3H3/0, createdBy=152c1940043, createdName=Lke, createdTime=Sat Aug 12 06:56:17 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232721, encodeId=978e232e21b8, content=很好的文章，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 12 06:47:45 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232711, encodeId=a1f9232e118c, content=好好看下，实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 12 06:44:30 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232704, encodeId=8aed232e046d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Aug 12 06:33:44 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232673, encodeId=90832326e3ed, content=学习了，谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Aug 12 00:43:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232640, encodeId=e2122326406d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Aug 12 00:21:09 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 Lke

    路过。。。。。。。。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=232790, encodeId=c5b6232e906b, content=皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Aug 12 09:33:07 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232726, encodeId=dfc5232e260b, content=路过。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEjPHcBWkEawnOHuvuXw3Lxjnzko8jRkakGyVZ27zRcmYACibkCom9Da1icAJBDFrbJelRNtMRic3H3/0, createdBy=152c1940043, createdName=Lke, createdTime=Sat Aug 12 06:56:17 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232721, encodeId=978e232e21b8, content=很好的文章，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 12 06:47:45 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232711, encodeId=a1f9232e118c, content=好好看下，实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 12 06:44:30 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232704, encodeId=8aed232e046d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Aug 12 06:33:44 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232673, encodeId=90832326e3ed, content=学习了，谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Aug 12 00:43:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232640, encodeId=e2122326406d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Aug 12 00:21:09 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 清风拂面

    很好的文章，谢谢分享

    0

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    2017-08-12 忠诚向上

    好好看下，实用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=232790, encodeId=c5b6232e906b, content=皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Aug 12 09:33:07 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232726, encodeId=dfc5232e260b, content=路过。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEjPHcBWkEawnOHuvuXw3Lxjnzko8jRkakGyVZ27zRcmYACibkCom9Da1icAJBDFrbJelRNtMRic3H3/0, createdBy=152c1940043, createdName=Lke, createdTime=Sat Aug 12 06:56:17 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232721, encodeId=978e232e21b8, content=很好的文章，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 12 06:47:45 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232711, encodeId=a1f9232e118c, content=好好看下，实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 12 06:44:30 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232704, encodeId=8aed232e046d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Aug 12 06:33:44 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232673, encodeId=90832326e3ed, content=学习了，谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Aug 12 00:43:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232640, encodeId=e2122326406d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Aug 12 00:21:09 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 刘煜

    学习了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=232790, encodeId=c5b6232e906b, content=皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Aug 12 09:33:07 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232726, encodeId=dfc5232e260b, content=路过。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEjPHcBWkEawnOHuvuXw3Lxjnzko8jRkakGyVZ27zRcmYACibkCom9Da1icAJBDFrbJelRNtMRic3H3/0, createdBy=152c1940043, createdName=Lke, createdTime=Sat Aug 12 06:56:17 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232721, encodeId=978e232e21b8, content=很好的文章，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 12 06:47:45 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232711, encodeId=a1f9232e118c, content=好好看下，实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 12 06:44:30 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232704, encodeId=8aed232e046d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Aug 12 06:33:44 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232673, encodeId=90832326e3ed, content=学习了，谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Aug 12 00:43:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232640, encodeId=e2122326406d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Aug 12 00:21:09 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 惠映实验室

    学习了，谢谢。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=232790, encodeId=c5b6232e906b, content=皮肤内抗原呈递细胞丰富有助于刺激免疫反应，因此皮内注射抗原进行疫苗接种是一个非常有吸引力的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Aug 12 09:33:07 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232726, encodeId=dfc5232e260b, content=路过。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLEjPHcBWkEawnOHuvuXw3Lxjnzko8jRkakGyVZ27zRcmYACibkCom9Da1icAJBDFrbJelRNtMRic3H3/0, createdBy=152c1940043, createdName=Lke, createdTime=Sat Aug 12 06:56:17 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232721, encodeId=978e232e21b8, content=很好的文章，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Aug 12 06:47:45 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232711, encodeId=a1f9232e118c, content=好好看下，实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 12 06:44:30 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232704, encodeId=8aed232e046d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Aug 12 06:33:44 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232673, encodeId=90832326e3ed, content=学习了，谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Aug 12 00:43:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232640, encodeId=e2122326406d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Aug 12 00:21:09 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 飛歌

    学习了很有用

    0

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