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Breast J:男性乳腺癌相关研究

2014-11-29 MedSci MedSci原创

Breast journal:男性乳腺癌相关研究 男性乳腺癌很罕见,占所有乳腺癌的1%,由于缺少随机对照试验,目前的证据是来源于小型单中心的研究,治疗方式参考女性乳腺癌的研究。 本单中心研究回顾性分析1995年1月-2009年12月诊断的男性乳腺癌患者,将本研究与现有的证据做对比,包括流行病学、病理学、临床特征、结局。 共纳入57名患者,平均年龄71.5岁,5年存活率55.6%,29名已

男性乳腺癌很罕见,占所有乳腺癌的1%,由于缺少随机对照试验,目前的证据是来源于小型单中心的研究,治疗方式参考女性乳腺癌的研究。

本单中心研究回顾性分析19951-200912月诊断的男性乳腺癌患者,将本研究与现有的证据做对比,包括流行病学、病理学、临床特征、结局。

共纳入57名患者,平均年龄71.55年存活率55.6%29名已去世(平均年龄79.4岁),41名患者经外科治疗、16名经保守治疗。78.9%为浸润性导管癌,97.6%表现为雌激素受体阳性。

过去的38年,男性乳腺癌发病率呈稳定较低水平,女性乳腺癌有所升高。但男性乳腺癌有地区分布差异:北美和欧洲发病率较高,亚洲较低,可能归因于感染性肝损伤所致的雌激素过低。男性乳腺癌随年龄增加而增加,在70岁左右发病率最高,初诊年龄较女性乳腺癌高5-10岁,本研究与过去的研究基本一致;经组织学研究发现浸润性导管癌比例较高(64-96%),可能是由于正常男性乳腺未受刺激因而缺少小叶结构之故本研究雌激素受体高表达,与过去的研究一致(ER 60-100%PR 40-86%;本研究肿瘤平均大小23.3mm,与过去的研究范围一致。男性乳腺癌较女性乳腺癌有更差的预后,可能与初诊使即为较晚期有关,除此之外还与初诊年龄较大、不规范的局部治疗有关,但本研究调整了上述影响因素发现,男性乳腺癌其实较女性乳腺癌患者有更好的存活。尽管有研究表明肿瘤大小和腋窝淋巴结状态与预后有关,但也有研究表明腋窝淋巴结状态与预后更相关

总之,男性乳腺癌在发病学、临床病例特征都不同于女性乳腺癌,仍需要大量临床研究将其与女性乳腺癌做比较。

原始出处:

Kaushik, M., M. Oliveira-Cunha, and S. Shokuhi, Male breast cancer: a single centre experience and current evidence. Breast J, 2014. 20(6): p. 674-5.

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    2014-12-02 cherishcqx

    国内有类似统计,但已经过时了

    0

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    2014-12-01 zhaojie88
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    2014-11-30 YSX135197a432m

    国内缺乏统计,

    0

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