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Head Face Med:体外冲击波治疗可阻碍牙齿移动

2018-11-22 MedSci MedSci原创

最近,加速牙齿移动一直是正畸研究的主题。手术促进正畸治疗已被证明是加速牙齿移动的有效方法;然而,这种手术是创伤性的,需要额外的手术,并可能增加术后并发症。在这项研究中,我们评估体外冲击波治疗(ESWT),一种非侵入性的牙槽骨再生方法,对大鼠正畸牙齿移动的影响。 选择10周龄的72只雄性大鼠,对10-cN闭合线圈镍钛弹簧进行单侧上颌第一磨牙移动。一组大鼠在能量通量密度为0.1 mJ/mm2时以

最近,加速牙齿移动一直是正畸研究的主题。手术促进正畸治疗已被证明是加速牙齿移动的有效方法;然而,这种手术是创伤性的,需要额外的手术,并可能增加术后并发症。在这项研究中,我们评估体外冲击波治疗(ESWT),一种非侵入性的牙槽骨再生方法,对大鼠正畸牙齿移动的影响。

选择10周龄的72只雄性大鼠,对10-cN闭合线圈镍钛弹簧进行单侧上颌第一磨牙移动。一组大鼠在能量通量密度为0.1 mJ/mm2时以500脉冲接受单次体外冲击波治疗,安装后立即以每秒5次脉冲的速率进行,而非ESWT治疗组作为对照组。在第3,7,14,21和28天处死大鼠用于牙齿移动评估和样品分析。进行了Faxitron射线照相,组织学,双骨标记和基因表达分析。在研究的第3,7和28天评估血清生物化学。Kruskal-Wallis方差分析用于确定组间的平均差异,并且通过Mann-Whitney-U检验分析多重比较,显着性水平= 0.05。

结果显示,与非ESWT处理的大鼠(0.44±0.09mm)中的牙齿移动相比,ESWT处理的大鼠(0.11±0.07mm)中的牙齿移动受到阻碍。ESWT上调了几种成骨细胞和破骨细胞基因标记物和细胞因子;然而,对破骨细胞的影响只是短暂的。双荧光骨标记显示ESWT处理后成骨细胞活性增加。组间系统RANKL/OPG比率无差异。

综上所述,该研究结果表明,ESWT在500脉冲,能量通量密度0.1 mJ/mm2增加成骨细胞和破骨细胞活动和不平衡骨重建导致大鼠牙齿移动受阻。

原始出处:

Phimon Atsawasuwan, Yinghua Chen, et al., Extracorporeal shockwave treatment impedes tooth movement in rats. Head Face Med. 2018; 14: 24.

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    2019-01-28 shanyongle
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    2018-11-24 zhouqu_8
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    2018-11-24 hb2008ye
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