Lancet：新方法可有效降低东南亚地区恶性疟流行

2018-04-25 zhangfan MedSci原创

研究认为，早期诊断、治疗以及正对性的大剂量强化治疗可显著降低东南亚地区恶性疟的发病率

恶性疟原虫疟疾仍是大湄公河区域的重要公共卫生难题。近日研究人员考察了恶性疟原虫疟疾的早期诊断、治疗及定向大量给药对该地区疟疾的预防效果。

研究在缅甸克伦邦四个镇开展，向参与研究的村庄提供快速诊断设备、蒿甲醚、本芴醇以及伯氨喹等药物。在研究过程中通过血样采集对疟疾的预防及复发情况进行考察，对患者进行每月一次二氢青蒿素+哌喹加单剂量伯氨喹治疗，持续3个月。研究终点是恶性疟原虫疟疾发病率变化。

365000名参与者中1222人接受早期诊断及治疗，疫区恶性疟原虫发病率下降了60-98%。研究期间总计进行272次流行病学调查，确定69个村庄为疫区热点地区，其发病率约是其他地区的2.7倍，其中50个热点地区接受大剂量药物治疗。早期诊断及治疗可显著降低热点地区的发病率，效果优于平均水平。大剂量治疗可5倍以上降低热点地区的疟疾发病率。截止2017年4月，79%的村庄实现至少6个月以上无恶性疟发病。研究期间青蒿素抗性K13分子标记野生型基因流行率稳定(39%； 249/631)。

研究认为，早期诊断、治疗以及正对性的大剂量强化治疗可显著降低东南亚地区恶性疟的发病率。

原始出处：

Jordi Landier et al. Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar： an observational study of a regional elimination programme.Lancet. 24 April 2018.

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#插入话题

插入图片

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2018-07-10 kord1982

#新方法#

81 0
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2019-03-24 howi

#Lancet#

87 0
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2018-04-26 张新亮1853311252142e2fm

好文章.学习了

97 0
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2018-04-25 清风拂面

谢谢分享学习

144 0
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2018-04-25 zdvfsadb

学习了

91 0
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2018-04-25 戒馋，懒，贪

谢谢分享学习了

114 0
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2018-04-25 1ddf0692m34(暂无匿称)

学习了.长知识

75 0

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