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Am J Dent:载药纳米粒子的抗菌就抗菌膜形成能力分析

2017-11-29 MedSci MedSci原创

本研究旨在对比洗必泰、青霉素、红霉素、克林霉素、四环素与负载万古霉素的银、二氧化钛和铁纳米颗粒的抗菌效果,并探究纳米颗粒对变形链球菌和血链球菌临床和标准菌株的协同抗菌和抗菌作用。研究人员从66名3〜5岁儿童收集变异链球菌和血链球菌菌株,然后将其暴露于氯己定、青霉素、红霉素、克林霉素、四环素以及装载万古霉素的银、二氧化钛和铁纳米颗粒中,通过微量稀释和盘扩散测试评估抗菌活性,1至5分钟后计数菌落形成单

本研究旨在对比洗必泰、青霉素、红霉素、克林霉素、四环素与负载万古霉素的银、二氧化钛和铁纳米颗粒的抗菌效果,并探究纳米颗粒对变形链球菌和血链球菌临床和标准菌株的协同抗菌和抗菌作用。

研究人员从66名3〜5岁儿童收集变异链球菌和血链球菌菌株,然后将其暴露于氯己定、青霉素、红霉素、克林霉素、四环素以及装载万古霉素的银、二氧化钛和铁纳米颗粒中,通过微量稀释和盘扩散测试评估抗菌活性,1至5分钟后计数菌落形成单位。通过微量滴定试验检查抗菌膜活性。

结果显示,与装载药物相比,单独使用纳米颗粒的最小抑制浓度(MIC)更高。最有效的抗菌方案是含有TiO2、Ag和Fe3O4的装载药物组,变异链球菌和血链球菌的MIC分别为0.019μg/ml和0.047μg/ml。此外,与其他抗生素和氯己定相比,这种组合方案的生物膜抑制浓度(BIC)和菌落形成单位最小。

综上所述,该研究结果表明,与其他纳米颗粒溶液、抗生素和氯己定相比,含有TiO2、Ag和Fe3O4的溶液对变异链球菌和血链球菌的最小抑菌浓度和抗菌膜浓度最低,可用于治疗和处理龋齿、牙菌斑和口腔感染

原始出处:

Lavaee F, Faez K, Faez K, Hadi N, Modaresi F. Antimicrobial and antibiofilm activity of silver, titanium dioxide and iron nano particles. Am J Dent. 2016 Dec;29(6):315-320.

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