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Clinica Chimica Acta：重型颅脑损伤患者血清可溶性TWEAK水平及其预后意义

2019-09-21 gladiator MedSci原创

重型颅脑损伤患者TWEAK水平
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严重创伤性脑损伤<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font-family:宋体;mso-bidi-font-family:&quot;Times New Ro

严重创伤性脑损伤(sTBI)的特点是死亡率高。肿瘤坏死因子样弱凋亡诱导因子(TWEAK)参与炎症反应。在此，研究人员测定了TWEAK水平对其预后的影响。

这是2014年12月至2017年12月进行的单中心前瞻性观察研究。本研究共纳入符合纳入标准的114例sTBI患者和随机选择的114例健康对照者。测定血清sTWEAK水平。患者随访直到死亡或完成 6个月。较差的结果为格拉斯哥结果评分1-3分。

与对照组相比，患者主要表现为较高的血清sTWEAK水平。血清sTWEAK水平与Glasgow昏迷评分、血清c反应蛋白水平呈显著相关。32例(28.1%)死亡，60例(52.6%)预后不良。接受者工作特性曲线分析清楚地表明，血清sTWEAK水平对6个月死亡率和不良预后具有较高的预测效果。血清sTWEAK成为6个月死亡率、总体生存率和不良预后的独立预测因子。

血清sTWEAK水平升高与炎症反应增加、创伤严重程度升高、sTBI后临床结局恶化密切相关。

原始出处：

Bei Tang，Ze Zhong，Serum soluble TWEAK levels in severe traumatic brain injury and its prognostic significance

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

 


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    2020-01-29 windight

    #CTA#

    0

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    2020-01-18 qblt

    #重型颅脑损伤#

    0

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    2019-09-23 fengting3

    #颅脑损伤#

    0

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    2019-09-23 ms3046638856685384

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1849734, encodeId=d5301849e3452, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jan 29 21:30:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633033, encodeId=def3163303341, content=<a href='/topic/show?id=828795e2833' target=_blank style='color:#2F92EE;'>#重型颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95728, encryptionId=828795e2833, topicName=重型颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3fa21990661, createdName=qblt, createdTime=Sat Jan 18 08:30:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379963, encodeId=871813e9963da, content=<a href='/topic/show?id=5f3c10046499' target=_blank style='color:#2F92EE;'>#颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100464, encryptionId=5f3c10046499, topicName=颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397834, encodeId=2d42139e834af, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546251, encodeId=ea88154625146, content=<a href='/topic/show?id=a6fa100185d7' target=_blank style='color:#2F92EE;'>#预后意义#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100185, encryptionId=a6fa100185d7, topicName=预后意义)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba9d13903217, createdName=haouestc, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373046, encodeId=066c3e3046e1, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sun Sep 22 10:04:49 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373041, encodeId=68ad3e304184, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Sep 22 06:51:35 CST 2019, time=2019-09-22, status=1, ipAttribution=)]
    2019-09-23 haouestc

    #预后意义#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1849734, encodeId=d5301849e3452, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jan 29 21:30:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633033, encodeId=def3163303341, content=<a href='/topic/show?id=828795e2833' target=_blank style='color:#2F92EE;'>#重型颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95728, encryptionId=828795e2833, topicName=重型颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3fa21990661, createdName=qblt, createdTime=Sat Jan 18 08:30:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379963, encodeId=871813e9963da, content=<a href='/topic/show?id=5f3c10046499' target=_blank style='color:#2F92EE;'>#颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100464, encryptionId=5f3c10046499, topicName=颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397834, encodeId=2d42139e834af, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546251, encodeId=ea88154625146, content=<a href='/topic/show?id=a6fa100185d7' target=_blank style='color:#2F92EE;'>#预后意义#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100185, encryptionId=a6fa100185d7, topicName=预后意义)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba9d13903217, createdName=haouestc, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373046, encodeId=066c3e3046e1, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sun Sep 22 10:04:49 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373041, encodeId=68ad3e304184, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Sep 22 06:51:35 CST 2019, time=2019-09-22, status=1, ipAttribution=)]
    2019-09-22 一天没事干

    很好的学习机会

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1849734, encodeId=d5301849e3452, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jan 29 21:30:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633033, encodeId=def3163303341, content=<a href='/topic/show?id=828795e2833' target=_blank style='color:#2F92EE;'>#重型颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95728, encryptionId=828795e2833, topicName=重型颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3fa21990661, createdName=qblt, createdTime=Sat Jan 18 08:30:00 CST 2020, time=2020-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379963, encodeId=871813e9963da, content=<a href='/topic/show?id=5f3c10046499' target=_blank style='color:#2F92EE;'>#颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100464, encryptionId=5f3c10046499, topicName=颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397834, encodeId=2d42139e834af, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546251, encodeId=ea88154625146, content=<a href='/topic/show?id=a6fa100185d7' target=_blank style='color:#2F92EE;'>#预后意义#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100185, encryptionId=a6fa100185d7, topicName=预后意义)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba9d13903217, createdName=haouestc, createdTime=Mon Sep 23 14:30:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373046, encodeId=066c3e3046e1, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sun Sep 22 10:04:49 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373041, encodeId=68ad3e304184, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Sep 22 06:51:35 CST 2019, time=2019-09-22, status=1, ipAttribution=)]
    2019-09-22 yjs木玉

    好好好好好好

    0

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