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JACC:IL-1β抑制剂不能降低糖尿病的发病风险

2018-05-26 MedSci MedSci原创

由白介素(IL)-1β介导的亚临床炎症参与了外周胰岛素抵抗的形成,本研究的目的旨在评估IL-1β抑制剂卡纳单抗能否减少糖尿病的发生。本研究纳入了10061名原发性心梗和高敏C反应蛋白(hsCRP)≥2 mg/l的患者,将其随机分成安慰剂组和卡纳单抗组,其中,有4057名患者在入组前就有糖尿病,4960名患者有糖尿病前期,仅1044名患者血糖水平是正常的。经过平均3.7年时间的随访,在入组前无糖尿病

由白介素(IL)-1β介导的亚临床炎症参与了外周胰岛素抵抗的形成,本研究的目的旨在评估IL-1β抑制剂卡纳单抗能否减少糖尿病的发生。

本研究纳入了10061名原发性心梗和高敏C反应蛋白(hsCRP)≥2 mg/l的患者,将其随机分成安慰剂组和卡纳单抗组,其中,有4057名患者在入组前就有糖尿病,4960名患者有糖尿病前期,仅1044名患者血糖水平是正常的。经过平均3.7年时间的随访,在入组前无糖尿病的患者中,hsCRP水平高的患者发生糖尿病的风险更高(p=0.003)。在每三个月接受150mg卡纳单抗治疗的患者中,其发生不良心血管事件的风险和安慰剂组无明显差异,尽管卡纳单抗能降低hsCRP和IL-6的水平,但其不能降低新发糖尿病的发生率(p=0.84)。另外,卡纳单抗能减少患者6-9个月的糖化血红蛋白水平,但远期的无明显效益。

研究结果显示,IL-1β抑制剂卡纳单抗不能降低糖尿病的发生风险。

原始出处:

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    2018-12-13 jklm09
  2. 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    2019-03-12 hbwxf
  3. 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    2018-05-28 一天没事干

    很好的学习机会

    0

  4. 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  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 26 15:12:29 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-28 rgjl
  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 26 15:12:29 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-28 jjjiang0202
  7. 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likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 26 16:22:18 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318770, encodeId=5f91318e70e8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Sat May 26 16:10:32 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318762, encodeId=0ab7318e626a, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 26 15:12:29 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-27 kafei

    了解了谢谢

    0

  8. 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likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 26 16:22:18 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318770, encodeId=5f91318e70e8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/11/eb1f237032e0bf07b10833fc3722e645.jpg, createdBy=2fed2145219, createdName=紫迎馨, createdTime=Sat May 26 16:10:32 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318762, encodeId=0ab7318e626a, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 26 15:12:29 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-26 清风拂面

    谢谢分享学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1851723, encodeId=4b231851e23e1, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Dec 13 15:38:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854040, encodeId=80311854040d1, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 26 15:12:29 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-26 紫迎馨

    学习

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 26 15:12:29 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-26 惠映实验室

    学习了.谢谢分享.

    0

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