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J Infect Chemother:CRE诱发的神经外科细菌性脑膜炎/脑炎的流行病学和危险因素

2020-12-11 MedSci原创 MedSci原创

本项回顾性研究旨在确定耐碳青霉烯肠杆菌科(CRE)相关脑膜炎/脑炎的流行病学特征,并阐明CRE神经外科感染的危险因素,研究结果已在线发表于J Infect Chemother。

本项回顾性研究旨在确定耐碳青霉烯肠杆菌科(CRE)相关脑膜炎/脑炎的流行病学特征,并阐明CRE神经外科感染的危险因素,研究结果已在线发表于J Infect Chemother。

研究人员对每位患者的病历进行回顾,提取20个关于危险因素的临床变量,通过多变量logistic分析对CRE-脑膜炎/脑炎进行评估。

 

结果显示,2012-2017年,神经外科脑膜炎/脑炎的阳性率为7.9%(2947/29605),肠杆菌科占所有细菌感染的6.3%(185/2947)。本研究中共有133个肠杆菌科包括26个CRE分离株。其中,单变量分析显示,CRE脑膜炎的风险因素为呼吸机、菌血症、重症监护室(ICU)入院、医院获得性肺炎和感染导致的死亡。多变量logistic分析显示,医院获得性肺炎和感染导致的死亡是CRE脑膜炎的独立风险因素。

综上所述,该研究结果表明,CRE是世界卫生组织(WHO)2016年公布的最严重的耐药菌之一,CRE引起的脑膜炎/脑炎是神经外科手术失败的重要标志,需要医生立即重视。

 

原始出处:

 

Zheng Guanghui, Liu Jing, et al., Epidemiology and risk factors of neurosurgical bacterial meningitis/encephalitis induced by carbapenem resistant Enterobacteriaceae. J Infect Chemother. 2020 Jan;26(1):101-106. doi: 10.1016/j.jiac.2019.07.023.  

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    2020-12-15 慎独

    学习学习

    0

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    2020-12-13 xugumin
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    2020-12-13 HinsMax
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    2020-12-12 求素颜

    不错

    0

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