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GUT: 胃肠道病毒感染以及肤质饮食会增加肠道自身免疫性疾病的发生

2020-07-18 MedSci原创 MedSci原创

有研究指出较高的麸质摄入,频繁的胃肠道感染以及腺病毒,肠病毒,轮状病毒是导致腹腔疾病的环境诱因。

背景及目的:

有研究指出较高的麸质摄入,频繁的胃肠道感染以及腺病毒,肠病毒,轮状病毒是导致腹腔疾病的环境诱因。但是,在乳糜泻的发展过程中,摄入的面筋量和病毒暴露之间是否存在相互作用尚不明确。这项研究调查了单独的病毒暴露或与麸质一起暴露是否会增加遗传易感儿童的腹腔疾病自身免疫(CDA)的风险。

方法:

在本项研究中,研究人员前瞻性地追踪了携带HLA风险单倍型DQ2和/或DQ8的儿童,并构建了巢式病例对照设计。通过这种设计,确定了83对CDA病例对照。CDA的中位年龄为31个月。通过基因组测序,进行全面的计算机病毒分析,分析了每月采集到2岁以下的粪便样品的病毒组成。

结果:

1至2岁之间的粪便肠病毒暴露累积次数与CDA风险增加有关。此外,粪便肠病毒的累积暴露与面筋消耗之间存在显着的相互作用。如果报告的麸质摄入量较高,则粪便肠病毒的风险增加。

结论:

1-2岁患儿频繁接触肠道病毒与CDA风险增加有关。肠道病毒与高筋蛋白摄入之间的相互作用所带来的风险增加表明这些因素在CDA发生中的累积作用。

原始出处:

Katri Lindfors. Et al. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. GUT.2020.  

 

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