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Neurology:颅脑损伤与患帕金森病风险

2015-02-21 李志行 译 MedSci原创

在以随访为主的病例对照研究中检验纵贯一生的颅脑损伤与帕金森病(PD)之间的联系。研究方法:我们确定了在1996–2009间丹麦10家神经中心内1705位诊断为PD的患者,并核实了他们病例中的诊断。患者根据性别和出生年份与随意从丹麦中心人口注册中心挑选的1785个对照组匹配。比值比(ORs)和95% 置信区间 (CIs)运用非条件逻辑回归进行估算。研究结果:我们观察到首发主要症状前的任何颅脑损伤与P

在以随访为主的病例对照研究中检验纵贯一生的颅脑损伤与帕金森病(PD)之间的联系。 研究方法: 我们确定了在1996–2009间丹麦10家神经中心内1705位诊断为PD的患者,并核实了他们病例中的诊断。患者根据性别和出生年份与随意从丹麦中心人口注册中心挑选的1785个对照组匹配。比值比(ORs)和95% 置信区间 (CIs)运用非条件逻辑回归进行估算。 研究结果: 我们观察到首发主要症状前的任何颅脑损伤与PD间没有关联(OR 1.02; 95% CI 0.88, 1.19)。检查颅脑损伤数目(1: OR 1.02; 95% CI 0.87, 1.20; ≥2: OR 1.03; 95% CI 0.72, 1.47)或因头部损伤而住院治疗(OR 0.89; 95% CI 0.70, 1.12)并没有表现出与PD间的关联。对954个至少有一处颅脑损伤的研究对象而言,并没有证据可以证明意识丧失(OR 0.89; 95% CI 0.67, 1.17),意识丧失的持续时间(≤1 minute: OR 0.93; 95% CI 0.58, 1.49; 1–5 minutes: OR 0.74; 9

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    2015-12-22 yinhl1978
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    2015-02-24 xjtumed09

    不错,学习!

    0

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