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Ann Neurol:直立性低血压对2型糖尿病认知的影响

2019-08-12 xing.T MedSci原创

这些数据表明,伴有OH的2型糖尿病患者具有短暂的、姿势介导的认知缺陷超过了不伴有OH的糖尿病患者发生的认知缺陷。了解OH对自主神经衰竭引起的认知影响很重要,特别是仅在坐位或仰卧位收集临床评估和神经影像学数据。

近日,神经病学领域权威取杂志Annals of Neurology上发表了一篇研究文章,该研究旨在评估符合直立性低血压(OH)诊断标准的血压降低(BP)对2型糖尿病患者认知功能的的影响。 

受试者为没有痴呆的2型糖尿病患者,包括107个没有OH的个体和94个具有OH(DMOH)的个体;还包括95名对照参与者。在仰卧和站立位置评估血压。对所有受试者进行详细的神经心理学评估。

DM和DMOH组之间在仰卧时的某些认知指标方面有统计学意义。对于不同认知领域的所有指标,包括执行功能、记忆、视觉空间技能、信息处理速度和注意力,站立姿势加剧并扩大了DMOH组的认知缺陷。当组特异性仰卧评分用作基线锚时,两个DM组在从仰卧位转变为直立位时表现出认知改变,DMOH组在记忆、视觉空间技能、执行功能和注意力方面表现出更广泛的神经心理缺陷,以及信息处理速度的也显著改变。

这些数据表明,伴有OH的2型糖尿病患者具有短暂的、姿势介导的认知缺陷超过了不伴有OH的糖尿病患者发生的认知缺陷。了解OH对自主神经衰竭引起的认知影响很重要,特别是仅在坐位或仰卧位收集临床评估和神经影像学数据。 

原始出处:

Jinbiao Zhang,et al.Effects of Orthostatic Hypotension on Cognition in Type 2 Diabetes Mellitus.Annals of Neurology. 2019.https://onlinelibrary.wiley.com/doi/10.1002/ana.25578

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    2019-09-30 yinhl1978
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    2019-08-13 130****4638

    血压和糖尿病之间关系密切。

    0

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    2019-08-12 misszhang

    谢谢MedSci提供最新的资讯

    0

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