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Crit Care Med:术前认知能力和术后谵妄与接受心脏手术后痴呆症发生独立相关!

2017-05-09 xing.T MedSci原创

该研究结果表明术前认知功能降低或术后谵妄的老年患者在心脏手术后5年内有发生痴呆症的风险。术前应对认知功能进行筛查,并对术后发生谵妄的患者应进行随访,以便及早发现痴呆症状及进行治疗。

近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,研究人员旨在探讨术后谵妄是否与心脏手术后5年内痴呆症的发生有关。

该研究为纵向队列研究,以瑞典莫奥大学医院胸心外科为基础。纳入了70岁或以上的患者(n=114),这些患者接受了常规的体外循环心脏手术,在2009年招募入研究时没有发生老年痴呆症。研究人员对参与者术前、术后拔管后1天、4天和第1年、3年、5年进行了结构性评估。患者进行了全面评估,包括认知和身体功能、合并的疾病、人口学特征和药物。根据第四版精神疾病诊断和统计手册的文本修订标准来诊断谵妄、抑郁症和痴呆症。

在随访5年期间,114名参与者中30名(26.3%)发展为痴呆症。术后谵妄发生在87%的参与者,这些参与者后来发展为痴呆症。多因素Logistic回归分析显示术前较低的简易精神状态检查评分(P<0.001;比值比为0.68;95%可信区间为0.54-0.84)和术后谵妄的发生(P=0.002;比值比为7.57;95%可信区间为2.15-26.65)与老年痴呆症的发生之间存在相关性。

该研究结果表明术前认知功能降低或术后谵妄的老年患者在心脏手术后5年内有发生痴呆症的风险。术前应对认知功能进行筛查,并对术后发生谵妄的患者应进行随访,以便及早发现痴呆症状及进行治疗。

原始出处:


Lingehall, Helena Claesson RN,  et al. Preoperative Cognitive Performance and Postoperative Delirium Are independently Associated With Future Dementia in Older People Who Have Undergone Cardiac Surgery: A Longitudinal Cohort Study. critical care medicine. http://journals.lww.com/ccmjournal/Abstract/publishahead/Preoperative_Cognitive_Performance_and.96599.aspx

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    2019-07-01 小微940490

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    2017-05-13 Boyinsh
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    2017-05-10 meiliwuxian

    观察这么久?

    0

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