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新型混合治疗方法可有效治疗儿童白血病

2016-08-02 佚名 生物谷

来自美国加州大学戴维斯分校和Ionis制药公司(原ISIS制药公司)的研究人员开发出一种混合治疗方法,利用单克隆抗体将反义DNA运送到急性淋巴细胞白血病细胞,这样既可以有效靶向癌细胞又能够减小治疗对健康细胞的毒性。相关研究发表在国际学术期刊Molecular Medicine上。 该研究表明一旦将这种具有治疗作用的反义DNA运送癌细胞就能够降低一种帮助癌细胞存活的蛋白(MXD3)的表达水平。这一

来自美国加州大学戴维斯分校和Ionis制药公司(原ISIS制药公司)的研究人员开发出一种混合治疗方法,利用单克隆抗体将反义DNA运送到急性淋巴细胞白血病细胞,这样既可以有效靶向癌细胞又能够减小治疗对健康细胞的毒性。相关研究发表在国际学术期刊Molecular Medicine上。

该研究表明一旦将这种具有治疗作用的反义DNA运送癌细胞就能够降低一种帮助癌细胞存活的蛋白(MXD3)的表达水平。这一最新的混合治疗方法已经在动物模型上表现出巨大前景,可以在杀伤ALL细胞的同时限制对健康细胞造成的损伤。

研究人员将抑制MXD3蛋白表达的反义DNA附着在结合CD22的单克隆抗体上,CD22是一种几乎只在ALL细胞和正常B细胞上表达的蛋白受体。一旦抗体与CD22结合,附着的反义DNA就会进入白血病细胞,抑制MXD3的合成。缺少了这种抗凋亡蛋白,ALL细胞就容易发生死亡。

这种混合治疗方法对体外培养的ALL细胞系和人源肿瘤异种移植小鼠模型都表现出有效的对抗作用,接受治疗的小鼠存活时间明显长于对照组。

这种方法具有很好的选择性,只能够靶向表达CD22的细胞,虽然健康的B细胞也会受到攻击,但是这种方法不会对造血干细胞和其他组织造成损伤。

这项研究已经表明该方法能够抑制MXD3的表达,但是研究人员表示他们还会继续研究该方法的作用机制,除此之外他们还希望将这种方法与其他治疗方法联合使用检测治疗效果。由于这种方法通过促进细胞死亡发挥作用,因此可能会使传统化疗药物变得更加有效。 

原始出处:

Noriko Satake1,2, Connie Duong1,2, Sakiko Yoshida1,2, Michael Oestergaard3, Cathy Chen1,2, Rachael Peralta3, Shuling Guo3, Punit P Seth3, Yueju Li4, Laurel Beckett4, Jong Chung1, Jan Nolta2, Nitin Nitin5, Joseph M Tuscano6.Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate.Molecular Medicine.2016


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    2016-09-08 ylzr123

    好文章,赞一个!深入学习,值得推广。

    0

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    2016-08-03 oo902

    有潜力的方法

    0

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