Baidu
map

Cell:自闭症或与肠胃病相关

2013-12-12 佚名 中国科学报

许多医生和父母反映自己身边的自闭症儿童通常都患有异常严重的胃肠道疾病,例如慢性便秘或腹泻。因此一些研究人员推测,在某些情况下,是境况不佳的肠道导致了疾病的产生,但是这样的推论一直以来都缺乏科学数据的支持。日前,一项具有挑战性的研究表明:解决胃肠道问题的益生菌疗法可以减轻小鼠自闭症的症状,而且该疗法对人类同样有效。【原文下载】 该研究的首席研究员、美国帕萨迪纳市加州理工

许多医生和父母反映自己身边的自闭症儿童通常都患有异常严重的胃肠道疾病,例如慢性便秘或腹泻。因此一些研究人员推测,在某些情况下,是境况不佳的肠道导致了疾病的产生,但是这样的推论一直以来都缺乏科学数据的支持。日前,一项具有挑战性的研究表明:解决胃肠道问题的益生菌疗法可以减轻小鼠自闭症的症状,而且该疗法对人类同样有效。【原文下载】

该研究的首席研究员、美国帕萨迪纳市加州理工学院微生物学家Sarkis Mazmanian表示,在已公布的研究中,自闭症患者的肠道疾病发病率差别很大——从0至80%以上不等,这就使得研究人员很难在两者之间建立起相关联系。不过,总体来说,这些证据似乎指向了一种联系。例如,去年美国疾病控制和预防中心的一项对数千名存在发育障碍的儿童的研究显示,与有其他类型疾病的儿童相比,自闭症儿童出现频繁腹泻或者结肠炎的比例要高两倍。

多年来,Mazmanian和同事一直在研究一种无毒菌株——脆弱拟杆菌对克罗恩氏病等疾病的影响,克罗恩氏病会导致肠道炎症,并使那些本应排出体外的有害物质通过细胞间的连接而渗漏。尽管研究人员不理解其中的机制,但这种细菌似乎能够恢复受损的肠道,可能有助于关闭细胞连接的缺口。

Mazmanian说:“这种可以修复肠道的机制可用于检测肠道异常是否能导致自闭症。”为了探讨这个问题,Mazmanian和同事利用自闭症小鼠模型展开了研究工作。研究发现,脆弱拟杆菌可以阻止小鼠肠道有害物质的渗漏,并使其肠道内微生物族群更接近正常小鼠。同时,自闭症小鼠在接受脆弱拟杆菌治疗后,在两项行为测试中的表现都与正常小鼠类似。该团队将报告发表在12月5日的《细胞》上。

纽约范斯坦医学研究所免疫学家Betty Diamond认为,新研究的一些成果非常令人激动。但是,她警告说,将脆弱拟杆菌等作为治疗手段用在人类身上还为时过早。

原文出处:

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK.Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders.Cell. 2013 Dec 3. pii: S0092-8674(13)01473-6. doi: 10.1016/j.cell.2013.11.024.【原文下载】


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1868730, encodeId=aaef1868e3055, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 12 22:21:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075792, encodeId=d8d020e579271, content=<a href='/topic/show?id=d0278163120' target=_blank style='color:#2F92EE;'>#肠胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81631, encryptionId=d0278163120, topicName=肠胃病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Tue Jul 08 20:21:00 CST 2014, time=2014-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958970, encodeId=376a19589e082, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jan 01 17:21:00 CST 2014, time=2014-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527546, encodeId=bcdf152e546a0, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532477, encodeId=eb7515324e75b, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1868730, encodeId=aaef1868e3055, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 12 22:21:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075792, encodeId=d8d020e579271, content=<a href='/topic/show?id=d0278163120' target=_blank style='color:#2F92EE;'>#肠胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81631, encryptionId=d0278163120, topicName=肠胃病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Tue Jul 08 20:21:00 CST 2014, time=2014-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958970, encodeId=376a19589e082, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jan 01 17:21:00 CST 2014, time=2014-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527546, encodeId=bcdf152e546a0, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532477, encodeId=eb7515324e75b, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1868730, encodeId=aaef1868e3055, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 12 22:21:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075792, encodeId=d8d020e579271, content=<a href='/topic/show?id=d0278163120' target=_blank style='color:#2F92EE;'>#肠胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81631, encryptionId=d0278163120, topicName=肠胃病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Tue Jul 08 20:21:00 CST 2014, time=2014-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958970, encodeId=376a19589e082, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jan 01 17:21:00 CST 2014, time=2014-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527546, encodeId=bcdf152e546a0, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532477, encodeId=eb7515324e75b, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=)]
    2014-01-01 维他命
  4. [GetPortalCommentsPageByObjectIdResponse(id=1868730, encodeId=aaef1868e3055, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 12 22:21:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075792, encodeId=d8d020e579271, content=<a href='/topic/show?id=d0278163120' target=_blank style='color:#2F92EE;'>#肠胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81631, encryptionId=d0278163120, topicName=肠胃病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Tue Jul 08 20:21:00 CST 2014, time=2014-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958970, encodeId=376a19589e082, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jan 01 17:21:00 CST 2014, time=2014-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527546, encodeId=bcdf152e546a0, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532477, encodeId=eb7515324e75b, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=)]
    2013-12-14 xiongke014
  5. [GetPortalCommentsPageByObjectIdResponse(id=1868730, encodeId=aaef1868e3055, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 12 22:21:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075792, encodeId=d8d020e579271, content=<a href='/topic/show?id=d0278163120' target=_blank style='color:#2F92EE;'>#肠胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81631, encryptionId=d0278163120, topicName=肠胃病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Tue Jul 08 20:21:00 CST 2014, time=2014-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958970, encodeId=376a19589e082, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jan 01 17:21:00 CST 2014, time=2014-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527546, encodeId=bcdf152e546a0, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532477, encodeId=eb7515324e75b, content=<a href='/topic/show?id=144d832140d' target=_blank style='color:#2F92EE;'>#胃病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83214, encryptionId=144d832140d, topicName=胃病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=975212339878, createdName=xiaoshitou, createdTime=Sat Dec 14 02:21:00 CST 2013, time=2013-12-14, status=1, ipAttribution=)]
    2013-12-14 xiaoshitou

相关资讯

PNAS:灰质变化可预测自闭症严重程度

近日,伦敦国王学院精神病学研究所与剑桥大学的科学家们发现,大脑皮层是覆盖着大脑的一层灰色物质,它们能影响有意识的思维、记忆、语言和其他功能,在大脑皮层内部神经连线的差别可能预测有自闭症谱系障碍(ASD)的成年人的社会与重复症状的严重程度。 成像研究已经表明,在患自闭症和没有患自闭症的人的白质内部信号以不同的方式通信,但是仍然不清楚皮层的灰质内部的神经连线如何受到影响。 在这项最新研究中,科

男性生育太晚孩子易得自闭症

全球每20分钟就有一个孩子被诊断为自闭症。目前,全世界自闭症患者已达6700万,中国的自闭症患儿已超过100万,而且患病率正在逐年上升。最新研究发现,自闭症不仅与遗传密不可分,也与家人的生活方式和环境污染有关。这项研究为人类认识自闭症打开了另一扇窗。 女童受虐与男性生育晚  增加后代自闭症风险 《美国医学会杂志·精神病学》发表的两项研究提示,童年受虐待的女性以及较晚做父亲的男性,所生

Nat Neurosci:基因Top3β缺陷导致一系列神经发育疾病

日前,刊登在《自然-神经科学》杂志上的两篇论文从遗传学和生物化学角度找到证据证明:RNA结合蛋白Top3β可能是导致精神分裂症、自闭症谱系障碍和智力缺陷的一种共同因素。结合之前一些研究认为的精神分裂症和自闭症可能拥有共同的遗传风险因素的结论,这两项新研究确定了与这些疾病共有的认知缺陷有关的潜在生物过程。【原文下载1】【原文下载2】 由于过去数个世纪的人口迁移模式的影响,芬

JADD:自闭症儿童更易出现肠胃问题

日前,来自加州大学戴维斯分校的研究人员发现,自闭症儿童出现便秘、腹泻和对食物敏感等肠胃问题的可能性是正常发育儿童的 6 到 8 倍。相关研究论文刊登在了近期出版的《自闭症与发育障碍杂志》(Journal of Autism and Developmental Disorders)上。【原文下载】 研究人员表示,长期以来,许多自闭症儿童的父母发现他们的孩子较易出现肠胃问题,但是人们对这些症状的

Nature:揭示催产素对大脑功能的潜在作用

在一个拥挤、喧闹的餐厅中,能够将注意力集中在你自己那桌的人们和他们之间的交谈上,是一种极为重要的能力。大脑中的神经细胞在分离有用信息和背景声之时也面临着类似的挑战。催产素似乎是这一过程中的一个关键元素。由于在促进社会和亲缘联系中起着重要的作用,催产素通常也被称作为“爱的激素”。 现在,来自斯坦福医学院与纽约大学神经科学研究所的科学家们破解了催产素在大脑中发挥神经激素作用的机制,其不仅减少了背景噪

自闭症可能与肿瘤基因相关

从表面上来看,自闭症和肿瘤是两种风马牛不相及的疾病。然而,研究这两种疾病的科学家们却意外地得出了同一个惊人的发现:某些自闭症患者携带有突变型的癌症或肿瘤基因,很可能正是这些基因突变导致了他们的脑部功能紊乱。 PTEN基因的突变可引发乳腺、结肠、甲状腺以及其他器官发生癌症。在携带该突变的儿童中,有10%患有自闭症。而在携带可导致某些类型的脑癌、肾癌以及若干器官(包括脑部)大型肿瘤的突变基因的儿

Baidu
map
Baidu
map
Baidu
map