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Stroke:脑出血后严重缺血性和出血性事件的五年风险

2019-04-16 xing.T 网络

由此可见,ICH幸存者发生颅内和颅外血管事件风险升高。缺血性或出血性风险特征根据ICH位置而变化,在深部ICH中具有更强的缺血性事件风险。针对ICH的部位,二级预防不仅应针对脑出血复发,还应针对脑外血管事件。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究旨在确定脑出血(ICH)幸存者中大血管事件的发生率和预测因子。

研究人员对来自法国里尔的颅内出血预后队列中的自发性ICH患者进行了一项前瞻性观察性队列研究。研究人员根据ICH位置分析了30天内存活患者的长期(颅内和颅外,缺血和出血)血管事件的发生率和预测因子,并进行了预先指定的亚组分析。研究人员进行了多变量分析(竞争风险分析,在随访期间将死亡视为竞争事件)。

从2004年11月至2009年3月期间入组的560例自发性ICH患者中,研究人员纳入了310例患者(中位年龄为70岁)。在ICH后5年,82名患者出现至少1例大血管事件,其发病率为20.0%(95%CI为15.7-24.7)。在整个队列中,缺血事件比出血事件更频繁。然而,根据ICH位置,发病率明显不同:深部ICH与未来缺血事件相关(亚风险比为1.85; 95%CI为1.01-3.40),而脑叶ICH与出血事件相关(亚风险比为2.38; 95%CI为1.17-4.86)。在深部ICH中,5年时缺血事件的发生率比出血事件的发生率高6倍。 

由此可见,ICH幸存者发生颅内和颅外血管事件风险升高。缺血性或出血性风险特征根据ICH位置而变化,在深部ICH中具有更强的缺血性事件风险。针对ICH的部位,二级预防不仅应针对脑出血复发,还应针对脑外血管事件。 

原始出处:

Barbara Casolla.et al.Five-Year Risk of Major Ischemic and Hemorrhagic Events After Intracerebral Hemorrhage.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.024449

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    2019-04-17 医者仁心5538

    学习了

    0

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    2019-04-16 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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