Baidu
map

老烟民可能对新冠病毒易感!成都学者研究称,ACE2不仅是2019新冠病毒受体,还促进炎症反应

2020-02-13 朱朱 文韬 中国循环杂志

2月5日,成都呼吸健康研究所李国平等在预印本平台medRxiv发表文章指出,在健康人群和有各种疾病的患者中,血管紧张素转换酶2(ACE2)的表达无明显差异,说明人群普遍易感,这与目前临床上观察到的结果一致。另外,基于吸烟者中ACE2的表达上调,研究者推断,长期吸烟者可能是新冠病毒感染的易感人群。研究还发现,健康人群与慢性气道疾病患者之间的ACE2表达没有显着差异。通过对SARS冠状病毒感染细胞中的

2月5日,成都呼吸健康研究所李国平等在预印本平台medRxiv发表文章指出,在健康人群和有各种疾病的患者中,血管紧张素转换酶2(ACE2)的表达无明显差异,说明人群普遍易感,这与目前临床上观察到的结果一致。

另外,基于吸烟者中ACE2的表达上调,研究者推断,长期吸烟者可能是新冠病毒感染的易感人群。

研究还发现,健康人群与慢性气道疾病患者之间的ACE2表达没有显着差异。

通过对SARS冠状病毒感染细胞中的ACE2进行分析,研究者发现,ACE2可能不仅仅是一个受体,它也参与感染后的调控过程,包括免疫应答、细胞因子分泌、病毒基因复制。

ACE2的过表达,还可诱导嗜中性粒细胞、NK细胞、Th17细胞、Th2细胞、Th1细胞、DC细胞、TNF-α分泌细胞的活化,增加炎症反应。

来源:Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV. medRxiv, February 05, 2020.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2032144, encodeId=18e6203214480, content=<a href='/topic/show?id=58eb8026932' target=_blank style='color:#2F92EE;'>#老烟民#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80269, encryptionId=58eb8026932, topicName=老烟民)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Tue Jun 23 11:09:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655989, encodeId=3e12165598916, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Mar 12 07:09:00 CST 2020, time=2020-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320883, encodeId=e4f513208837d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382993, encodeId=e22813829939a, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027148, encodeId=0eac102e148dd, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Feb 13 18:09:00 CST 2020, time=2020-02-13, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2032144, encodeId=18e6203214480, content=<a href='/topic/show?id=58eb8026932' target=_blank style='color:#2F92EE;'>#老烟民#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80269, encryptionId=58eb8026932, topicName=老烟民)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Tue Jun 23 11:09:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655989, encodeId=3e12165598916, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Mar 12 07:09:00 CST 2020, time=2020-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320883, encodeId=e4f513208837d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382993, encodeId=e22813829939a, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027148, encodeId=0eac102e148dd, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Feb 13 18:09:00 CST 2020, time=2020-02-13, status=1, ipAttribution=)]
    2020-03-12 shanyongle
  3. [GetPortalCommentsPageByObjectIdResponse(id=2032144, encodeId=18e6203214480, content=<a href='/topic/show?id=58eb8026932' target=_blank style='color:#2F92EE;'>#老烟民#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80269, encryptionId=58eb8026932, topicName=老烟民)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Tue Jun 23 11:09:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655989, encodeId=3e12165598916, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Mar 12 07:09:00 CST 2020, time=2020-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320883, encodeId=e4f513208837d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382993, encodeId=e22813829939a, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027148, encodeId=0eac102e148dd, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Feb 13 18:09:00 CST 2020, time=2020-02-13, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2032144, encodeId=18e6203214480, content=<a href='/topic/show?id=58eb8026932' target=_blank style='color:#2F92EE;'>#老烟民#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80269, encryptionId=58eb8026932, topicName=老烟民)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Tue Jun 23 11:09:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655989, encodeId=3e12165598916, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Mar 12 07:09:00 CST 2020, time=2020-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320883, encodeId=e4f513208837d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382993, encodeId=e22813829939a, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027148, encodeId=0eac102e148dd, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Feb 13 18:09:00 CST 2020, time=2020-02-13, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2032144, encodeId=18e6203214480, content=<a href='/topic/show?id=58eb8026932' target=_blank style='color:#2F92EE;'>#老烟民#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80269, encryptionId=58eb8026932, topicName=老烟民)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Tue Jun 23 11:09:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655989, encodeId=3e12165598916, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Mar 12 07:09:00 CST 2020, time=2020-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320883, encodeId=e4f513208837d, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382993, encodeId=e22813829939a, content=<a href='/topic/show?id=b4c118301c' target=_blank style='color:#2F92EE;'>#ACE2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1830, encryptionId=b4c118301c, topicName=ACE2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Sat Feb 15 06:09:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027148, encodeId=0eac102e148dd, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Feb 13 18:09:00 CST 2020, time=2020-02-13, status=1, ipAttribution=)]
    2020-02-13 公卫新人

    新冠肺炎,疫情何时才能消失

    0

相关资讯

国家卫健委全新解释:尚无证据显示新冠病毒通过气溶胶传播

空气中是否有新型冠状病毒?还能开窗通风吗?2月9日,国家卫建委官方微博@健康中国 发布了一系列新型冠状病毒科普知识,对于新冠肺炎的主要传播途径的最新解释是,气溶胶和粪—口等传播途径尚待进一步明确。主要传播途径仍是呼吸道飞沫传播和接触传播新型冠状病毒主要的传播途径是什么?@健康中国表示,在目前,新型冠状病毒主要的传播途径还是呼吸道飞沫传播和接触传播,气溶胶和粪—口等传播途径尚待进一步明确。通过流行病

Nat Rev Drug Dis:新冠病毒治疗方案

2月10日,Nature Reviews Drug Discovery发表了题为“Therapeutic options for the 2019 novel coronavirus (2019-nCoV)”的评论文章,讨论了利用现有抗病毒药物治疗新型冠状病毒(2019-nCoV)的潜力。

全新8866例回顾分析:每一例新冠感染病人传染3.77人(R0 3.77)

背景:正在中国爆发的2019新型冠状病毒(2019-nCoV)疫情已经引发世界卫生组织宣布此为国际公共卫生紧急事件(PHEIC)。办法:此文分析了截至2020年1月26日中国疾病控制与预防中心收到的所有2019-nCoV(2019新型冠状病毒)感染病例。我们在人口统计学分组和基线条件之间比较了发病率和死亡率,根据传播模型估算了病死率(CFRs)和基本再生数R0值。结果:截至2020年1月26日,3

北京将部分咽拭子检测阴性患者按照新冠病毒确诊病人管理

日前,一则消息称,中日友好医院出现一名三次咽拭子检测均为阴性、通过下呼吸道样本才确诊新冠肺炎的患者。作为新冠病毒肺炎病人定点收治医疗机构,首都医科大学附属北京佑安医院近期也遇到类似病例。2月8日,北京佑安医院感染综合科主任梁连春在接受健康界采访时表示,医院已将部分临床和影像表现非常明确但咽拭子检测为阴性的病人,按照新冠病毒肺炎确诊病人进行治疗和管理。健康界:目前佑安医院接诊新冠病毒肺炎病人情况如何

加州大学优化基因组浏览器,助力新冠病毒研究

加州大学圣克鲁斯分校(UCSC)基因组研究所已经发布了2019-nCoV的完整生物分子代码,供全世界的研究人员使用。UCSC基因浏览器依托2000年人类基因组计划建成,旨在通过初级处理,将基因组信息的细节可视化、共享化。此次针对2019-nCoV的代码更新,将大大易化全球研究人员的攻坚环节。2019-nCoV病毒的样品已在世界各实验室处理分析,有关其遗传密码的原始信息已发送至位于马里兰州贝塞斯达的

柳叶刀发布9名新冠病毒感染孕妇的研究,暂未发现母婴垂直传播证据

近日,世界卫生组织将新型冠状病毒感染的疾病命名为“COVID-19 (Corona Virus Disease 2019)”。国际病毒分类委员会将新型冠状病毒命名为“SARS-CoV-2(Severe Acute Respiratory Syndrome Coronavirus 2)”。2020年2月12日,柳叶刀在线发表了一篇文章“Clinical characteristics and i

Baidu
map
Baidu
map
Baidu
map