Diabetologia：联合基因组学和流行病学（PAGE）从人口结构精细定位研究血糖遗传学的跨性别特征

2017-12-31 MedSci MedSci原创

近日，国际杂志《Diabetologia》上在线发表一项关于联合基因组学和流行病学（PAGE）从人口结构精细定位研究血糖遗传学的跨性别特征结果的研究。非糖尿病个体空腹血糖和空腹胰岛素水平升高是糖代谢异常的标志，也是2型糖尿病的高风险因素。全基因组关联研究发现超过50个SNP与这些性状相关。这些基因座中的大部分都是在欧洲人群中发现的，并没有经过一项功能强大的多民族研究的测试。研究人员假设一

近日，国际杂志《Diabetologia》上在线发表一项关于联合基因组学和流行病学（PAGE）从人口结构精细定位研究血糖遗传学的跨性别特征结果的研究。非糖尿病个体空腹血糖和空腹胰岛素水平升高是糖代谢异常的标志，也是2型糖尿病的高风险因素。全基因组关联研究发现超过50个SNP与这些性状相关。这些基因座中的大部分都是在欧洲人群中发现的，并没有经过一项功能强大的多民族研究的测试。研究人员假设一个大型的，多民族的，精细定位的血糖性状遗传研究将确定新的以前以欧洲为中心的研究没有发现的人口特异性的关联。研究人员使用Metabochip对多达26,760名无亲缘关系的非糖尿病个体，主要是西班牙裔/拉丁裔和非洲裔祖先进行的多民族研究进行了基因分型。进行种族/民族特异性线性回归分析的空腹葡萄糖和空腹胰岛素的荟萃分析。研究人员试图复制39个空腹血糖和17个空腹胰岛素基因位点。通过在15个区域中的顺序条件分析进行遗传精细定位，其中包括最初报道的SNP关联和SNP标记的更密集的覆盖。此外，进行全基因组范围的分析以发现新的空腹血糖和空腹胰岛素基因位点。使用生物信息学功能注释进一步检查了最显著的SNP关联。

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2018-04-29 zz70

#联合基因#

62 0
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2018-06-24 ms5439512287675881

#BET#

69 0
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2018-03-08 李研东

#遗传学#

59 0
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2018-01-19 1dd8c52fm63(暂无匿称)

了解了解.学习学习

107 0
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2018-01-10 1dd8c52fm63(暂无匿称)

学习学习.了解了解

107 0
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2018-01-02 xugumin

#流行病#

110 0
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2018-01-02 gwc385

#基因组学#

82 0
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2018-01-02 1dd8c52fm63(暂无匿称)

学习学习.继续关注

116 0
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2018-03-27 ms9608593228839890

#DIA#

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